Jennifer B Permuth1,2, Kaleena B Dezsi1, Shraddha Vyas1, Karla N Ali1, Toni L Basinski1, Ovie A Utuama1, Jason W Denbo2, Jason Klapman2, Aamir Dam2, Estrella Carballido2, Dae Won Kim2, Jose M Pimiento2, Benjamin D Powers2, Amy K Otto3, Jung W Choi4, Dung-Tsa Chen5, Jamie K Teer5, Francisca Beato2, Alina Ward6, Elena M Cortizas7, Suzanne Y Whisner8, Iverson E Williams9, Andrea N Riner9, Kenneth Tardif10, Vic Velanovich11, Andreas Karachristos11, Wade G Douglas12, Adrian Legaspi13, Bassan J Allan6, Kenneth Meredith14, Manual A Molina-Vega15, Philip Bao16, Jamii St Julien10, Kevin L Huguet10, Lee Green17, Folakemi T Odedina18, Nagi B Kumar1, Vani N Simmons17, Thomas J George19, Susan T Vadaparampil17,20, Pamela J Hodul2, J Pablo Arnoletti21, Ziad T Awad22, Debashish Bose23, Kun Jiang24, Barbara A Centeno24, Clement K Gwede17, Mokenge Malafa2, Sarah M Judge25, Andrew R Judge25, Daniel Jeong4, Mark Bloomston6, Nipun B Merchant26, Jason B Fleming2, Jose G Trevino9,27. 1. Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. 2. Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. 3. Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL 33612, USA. 4. Department of Diagnostic Imaging and Interventional Radiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. 5. Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. 6. Lee Health Regional Cancer Center, Fort Myers, FL 33905, USA. 7. Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. 8. Cancer Institute, Advent Health Orlando, Orlando, FL 32804, USA. 9. College of Medicine, University of Florida, Gainesville, FL 32610, USA. 10. Department of Surgery, St. Anthony's Hospital, St. Petersburg, FL 33705, USA. 11. Tampa General Hospital, University of South Florida, Tampa, FL 33606, USA. 12. Division of Surgery, Tallahassee Memorial Healthcare, Department of Clinical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32308, USA. 13. Center for Advanced Surgical Oncology at Palmetto General Hospital, Tenet Healthcare Palmetto General, Hialeah, FL 33016, USA. 14. Department of Gastrointestinal Oncology, Brian Jellison Cancer Institute, Sarasota Memorial Hospital, Sarasota, FL 34239, USA. 15. Lakeland Regional Health, Lakeland, FL 33805, USA. 16. Department of Surgical Oncology, Mount Sinai Medical Center, Miami Beach, FL 33140, USA. 17. Department of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. 18. Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL 32610, USA. 19. Division of Oncology, Department of Medicine, University of Florida, Gainesville, FL 32610, USA. 20. Office of Community Outreach, Engagement, and Equity, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. 21. Center for Surgical Oncology, Advent Health Orlando, Orlando, FL 32804, USA. 22. Surgery, University of Florida-Jacksonville, Jacksonville, FL 32209, USA. 23. Surgical Oncology, University of Florida-Orlando, Orlando, FL 32806, USA. 24. Department of Pathology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. 25. Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA. 26. Department of Surgical Oncology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. 27. Division of Surgical Oncology, Department of Surgery, School of Medicine, Virginia Commonwealth University, Richmond, VA 23219, USA.
Abstract
Background: Well-annotated, high-quality biorepositories provide a valuable platform to support translational research. However, most biorepositories have poor representation of minority groups, limiting the ability to address health disparities. Methods: We describe the establishment of the Florida Pancreas Collaborative (FPC), the first state-wide prospective cohort study and biorepository designed to address the higher burden of pancreatic cancer (PaCa) in African Americans (AA) compared to Non-Hispanic Whites (NHW) and Hispanic/Latinx (H/L). We provide an overview of stakeholders; study eligibility and design; recruitment strategies; standard operating procedures to collect, process, store, and transfer biospecimens, medical images, and data; our cloud-based data management platform; and progress regarding recruitment and biobanking. Results: The FPC consists of multidisciplinary teams from fifteen Florida medical institutions. From March 2019 through August 2020, 350 patients were assessed for eligibility, 323 met inclusion/exclusion criteria, and 305 (94%) enrolled, including 228 NHW, 30 AA, and 47 H/L, with 94%, 100%, and 94% participation rates, respectively. A high percentage of participants have donated blood (87%), pancreatic tumor tissue (41%), computed tomography scans (76%), and questionnaires (62%). Conclusions: This biorepository addresses a critical gap in PaCa research and has potential to advance translational studies intended to minimize disparities and reduce PaCa-related morbidity and mortality.
Background: Well-annotated, high-quality biorepositories provide a valuable platform to support translational research. However, most biorepositories have poor representation of minority groups, limiting the ability to address health disparities. Methods: We describe the establishment of the Florida Pancreas Collaborative (FPC), the first state-wide prospective cohort study and biorepository designed to address the higher burden of pancreatic cancer (PaCa) in African Americans (AA) compared to Non-Hispanic Whites (NHW) and Hispanic/Latinx (H/L). We provide an overview of stakeholders; study eligibility and design; recruitment strategies; standard operating procedures to collect, process, store, and transfer biospecimens, medical images, and data; our cloud-based data management platform; and progress regarding recruitment and biobanking. Results: The FPC consists of multidisciplinary teams from fifteen Florida medical institutions. From March 2019 through August 2020, 350 patients were assessed for eligibility, 323 met inclusion/exclusion criteria, and 305 (94%) enrolled, including 228 NHW, 30 AA, and 47 H/L, with 94%, 100%, and 94% participation rates, respectively. A high percentage of participants have donated blood (87%), pancreatic tumor tissue (41%), computed tomography scans (76%), and questionnaires (62%). Conclusions: This biorepository addresses a critical gap in PaCa research and has potential to advance translational studies intended to minimize disparities and reduce PaCa-related morbidity and mortality.
Entities:
Keywords:
biorepository; cancer disparities; pancreatic cancer; prospective cohort; underserved populations
Authors: Jennifer B Permuth; Shraddha Vyas; Jiannong Li; Dung-Tsa Chen; Daniel Jeong; Jung W Choi Journal: Front Oncol Date: 2021-07-22 Impact factor: 6.244