Literature DB >> 33671866

Food-Derived Pharmacological Modulators of the Nrf2/ARE Pathway: Their Role in the Treatment of Diseases.

Feijie Zhao1, Xinxin Ci2, Xiaxia Man1, Jiajia Li1, Zhentong Wei1, Songling Zhang1.   

Abstract

Oxidative stress, which refers to unbalanced accumulation of reactive oxygen species (ROS) levels in cells, has been linked to acute and chronic diseases. Nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) pathway plays a vital role in regulating cytoprotective genes and enzymes in response to oxidative stress. Therefore, pharmacological regulation of Nrf2/ARE pathway is an effective method to treat several diseases that are mainly characterized by oxidative stress and inflammation. Natural products that counteract oxidative stress by modulating Nrf2 have contributed significantly to disease treatment. In this review, we focus on bioactive compounds derived from food that are Nrf2/ARE pathway regulators and describe the molecular mechanisms for regulating Nrf2 to exert favorable effects in experimental models of diseases.

Entities:  

Keywords:  Nrf2; bioactive compounds; diseases; food; oxidative stress

Mesh：

Substances：

Year:  2021        PMID： 33671866      PMCID： PMC7918973          DOI： 10.3390/molecules26041016

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  100 in total

Review 1.  Mechanistic studies of the Nrf2-Keap1 signaling pathway.

Authors:  Donna D Zhang
Journal:  Drug Metab Rev       Date:  2006       Impact factor: 4.518

2.  Curcumin prevents high glucose damage in retinal pigment epithelial cells through ERK1/2-mediated activation of the Nrf2/HO-1 pathway.

Authors:  Claudio Bucolo; Filippo Drago; Rosa Maisto; Giovanni Luca Romano; Velia D'Agata; Grazia Maugeri; Salvatore Giunta
Journal:  J Cell Physiol       Date:  2019-02-15       Impact factor: 6.384

3.  Naringenin-induced HO-1 ameliorates high glucose or free fatty acids-associated apoptosis via PI3K and JNK/Nrf2 pathways in human umbilical vein endothelial cells.

Authors:  Jian Feng; Jing Luo; Li Deng; Yi Zhong; Xing Wen; Ying Cai; Jiafu Li
Journal:  Int Immunopharmacol       Date:  2019-07-25       Impact factor: 4.932

4.  Curcumin inhibits proliferation of breast cancer cells through Nrf2-mediated down-regulation of Fen1 expression.

Authors:  Bin Chen; Youzhi Zhang; Yang Wang; Jun Rao; Xiaomei Jiang; Zihui Xu
Journal:  J Steroid Biochem Mol Biol       Date:  2014-01-30       Impact factor: 4.292

Review 5.  Shaping the Nrf2-ARE-related pathways in Alzheimer's and Parkinson's diseases.

Authors:  Lígia Fão; Sandra I Mota; A Cristina Rego
Journal:  Ageing Res Rev       Date:  2019-08-12       Impact factor: 10.895

6.  In vivo modulation of the Parkinsonian phenotype by Nrf2.

Authors:  Neal C Burton; Thomas W Kensler; Tomás R Guilarte
Journal:  Neurotoxicology       Date:  2006-08-05       Impact factor: 4.294

7.  The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-κB acetylation.

Authors:  Xiang-Ping Peng; Xiao-Hong Li; Yang Li; Xiao-Ting Huang; Zi-Qiang Luo
Journal:  Int Immunopharmacol       Date:  2019-03-19       Impact factor: 4.932

8.  Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells.

Authors:  Aruna Kode; Saravanan Rajendrasozhan; Samuel Caito; Se-Ran Yang; Ian L Megson; Irfan Rahman
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2007-12-27       Impact factor: 5.464

9.  NRF2 mitigates acute alcohol-induced hepatic and pancreatic injury in mice.

Authors:  Jing Sun; Jingqi Fu; Yang Zhong; Lu Li; Chengjie Chen; Xiaolei Wang; Linlin Wang; Yongyong Hou; Huihui Wang; Rui Zhao; Xixuan Zhang; Masayuki Yamamoto; Yuanyuan Xu; Jingbo Pi
Journal:  Food Chem Toxicol       Date:  2018-09-21       Impact factor: 6.023

10.  Helenalin from Centipeda minima ameliorates acute hepatic injury by protecting mitochondria function, activating Nrf2 pathway and inhibiting NF-κB activation.

Authors:  Yan Li; Yongmei Zeng; Quanfang Huang; Shujuan Wen; Yuanyuan Wei; Ya Chen; Xiaolin Zhang; Facheng Bai; Zhongpeng Lu; Jinbin Wei; Xing Lin
Journal:  Biomed Pharmacother       Date:  2019-09-11       Impact factor: 6.529
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  3 in total

1.  Soy-Derived Equol Induces Antioxidant Activity in Zebrafish in an Nrf2-Independent Manner.

Authors:  Asami Watanabe; Kyoji Muraki; Junya Tamaoki; Makoto Kobayashi
Journal:  Int J Mol Sci       Date:  2022-05-08       Impact factor: 6.208

Review 2.  Recent Advances in Understanding Nrf2 Agonism and Its Potential Clinical Application to Metabolic and Inflammatory Diseases.

Authors:  Min-Ji Kim; Jae-Han Jeon
Journal:  Int J Mol Sci       Date:  2022-03-05       Impact factor: 5.923

Review 3.  Nuclear Factor Erythroid-2-Related Factor 2 Signaling in the Neuropathophysiology of Inherited Metabolic Disorders.

Authors:  Bianca Seminotti; Mateus Grings; Paolo Tucci; Guilhian Leipnitz; Luciano Saso
Journal:  Front Cell Neurosci       Date:  2021-11-26       Impact factor: 5.505
  3 in total

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