| Literature DB >> 33671269 |
Yoo Jung Yi1, Do Hee Kim1, Suchan Chang1, Yeonhee Ryu2, Sang Chan Kim3, Hee Young Kim1.
Abstract
Visceral pain frequently produces referred pain at somatic sites due to the convergence of somatic and visceral afferents. In skin overlying the referred pain, neurogenic spots characterized by hyperalgesia, tenderness and neurogenic inflammation are found. We investigated whether neurogenic inflammatory spots function as acupoints in the rat model of bile duct ligation-induced liver injury. The majority of neurogenic spots were found in the dorsal trunk overlying the referred pain and matched with locations of acupoints. The spots, as well as acupoints, showed high electrical conductance and enhanced expression of the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP). Electroacupuncture at neurogenic spots reduced serum hepatocellular enzyme activities and histological patterns of acute liver injury in bile duct ligation (BDL) rats. The results suggest that the neurogenic spots have therapeutic effects as acupoints on hepatic injury in bile-duct ligated rats.Entities:
Keywords: calcitonin gene-related peptide; electroacupuncture; liver injury; neurogenic inflammation; substance P
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Year: 2021 PMID： 33671269 PMCID： PMC7922595 DOI： 10.3390/ijms22041974
Source DB: PubMed Journal: Int J Mol Sci ISSN： 1422-0067 Impact factor: 5.923