Literature DB >> 33670633

Demonstration of Green Solvent Performance on O,S,N-Heterocycles Synthesis: Metal-Free Click Chemistry and Buchwald-Hartwig Coupling.

Joana F Campos1, Manon Cailler1, Remi Claudel1, Benjamin Prot1, Thierry Besson2, Sabine Berteina-Raboin1.   

Abstract

The development of new and greener approaches to organic synthesis has been a trend in recent years. Continuing the latest publications of our team, in this work, we demonstrate the efficiency of three solvents: eucalyptol (1,8-cineole), cyclopentyl methyl ether (CPME), and 2-methyltetrahydrofuran (2-MeTHF) for the synthesis of O,S,N-heterocyclic compounds.

Entities:  

Keywords:  2-methyltetrahydrofuran; O,S,N-heterocycles; cyclopentyl methyl ether; eucalyptol; green solvent; greener methodology

Mesh：

Substances：

Year:  2021        PMID： 33670633      PMCID： PMC7922032          DOI： 10.3390/molecules26041074

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  5 in total

Review 1.  Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among U.S. FDA approved pharmaceuticals.

Authors:  Edon Vitaku; David T Smith; Jon T Njardarson
Journal:  J Med Chem       Date:  2014-10-07       Impact factor: 7.446

Review 2.  Rings in drugs.

Authors:  Richard D Taylor; Malcolm MacCoss; Alastair D G Lawson
Journal:  J Med Chem       Date:  2014-02-17       Impact factor: 7.446

3.  Green and Sustainable Solvents in Chemical Processes.

Authors:  Coby J Clarke; Wei-Chien Tu; Oliver Levers; Andreas Bröhl; Jason P Hallett
Journal:  Chem Rev       Date:  2018-01-04       Impact factor: 60.622

4.  Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies.

Authors:  Agnese C Pippione; Stefano Sainas; Parveen Goyal; Ingela Fritzson; Gustavo C Cassiano; Alessandro Giraudo; Marta Giorgis; Tatyana A Tavella; Renzo Bagnati; Barbara Rolando; Rhawnie Caing-Carlsson; Fabio T M Costa; Carolina Horta Andrade; Salam Al-Karadaghi; Donatella Boschi; Rosmarie Friemann; Marco L Lolli
Journal:  Eur J Med Chem       Date:  2018-11-22       Impact factor: 6.514

5.  A Greener and Efficient Method for Nucleophilic Aromatic Substitution of Nitrogen-Containing Fused Heterocycles.

Authors:  Joana F Campos; Mohammed Loubidi; Marie-Christine Scherrmann; Sabine Berteina-Raboin
Journal:  Molecules       Date:  2018-03-18       Impact factor: 4.411
  5 in total

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