Literature DB >> 33670047

Oxytocin in Schizophrenia: Pathophysiology and Implications for Future Treatment.

Kah Kheng Goh1,2, Chun-Hsin Chen1,2,3, Hsien-Yuan Lane4,5,6.   

Abstract

Schizophrenia is a form of mental disorder that is behaviorally characterized by abnormal behavior, such as social function deficits or other behaviors that are disconnected from reality. Dysregulation of oxytocin may play a role in regulating the expression of schizophrenia. Given oxytocin's role in social cognition and behavior, a variety of studies have examined the potential clinical benefits of oxytocin in improving the psychopathology of patients with schizophrenia. In this review, we highlight the evidence for the role of endogenous oxytocin in schizophrenia, from animal models to human studies. We further discuss the potential of oxytocin as a therapeutic agent for schizophrenia and its implication in future treatment.

Entities:  

Keywords:  oxytocin; psychopathology; schizophrenia; social cognition

Mesh：

Substances：

Year:  2021        PMID： 33670047      PMCID： PMC7926349          DOI： 10.3390/ijms22042146

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  162 in total

1.  Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia.

Authors:  Leah H Rubin; Siyi Li; Li Yao; Sarah K Keedy; James L Reilly; Scot K Hill; Jeffrey R Bishop; C Sue Carter; Hossein Pournajafi-Nazarloo; Lauren L Drogos; Elliot Gershon; Godfrey D Pearlson; Carol A Tamminga; Brett A Clementz; Matcheri S Keshavan; Su Lui; John A Sweeney
Journal:  Schizophr Res       Date:  2018-07-06       Impact factor: 4.939

2.  A single dose of oxytocin nasal spray improves higher-order social cognition in schizophrenia.

Authors:  Adam J Guastella; Philip B Ward; Ian B Hickie; Sara Shahrestani; Marie Antoinette Redoblado Hodge; Elizabeth M Scott; Robyn Langdon
Journal:  Schizophr Res       Date:  2015-07-03       Impact factor: 4.939

3.  A sniff of trust: meta-analysis of the effects of intranasal oxytocin administration on face recognition, trust to in-group, and trust to out-group.

Authors:  Marinus H Van IJzendoorn; Marian J Bakermans-Kranenburg
Journal:  Psychoneuroendocrinology       Date:  2011-07-29       Impact factor: 4.905

4.  Victory is its own reward: oxytocin increases costly competitive behavior in schizophrenia.

Authors:  Ellen R Bradley; Johanna Brustkern; Lize De Coster; Wouter van den Bos; Samuel M McClure; Alison Seitz; Joshua D Woolley
Journal:  Psychol Med       Date:  2019-04-04       Impact factor: 7.723

5.  Inhaled oxytocin amplifies both vicarious reinforcement and self reinforcement in rhesus macaques (Macaca mulatta).

Authors:  Steve W C Chang; Joseph W Barter; R Becket Ebitz; Karli K Watson; Michael L Platt
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-03       Impact factor: 11.205

6.  Social approach and avoidance behaviour for negative emotions is modulated by endogenous oxytocin and paranoia in schizophrenia.

Authors:  Elliot C Brown; Cumhur Tas; Duygu Kuzu; Aysen Esen-Danaci; Karin Roelofs; Martin Brüne
Journal:  Psychiatry Res       Date:  2014-07-08       Impact factor: 3.222

7.  Manipulation of the oxytocin system alters social behavior and attraction in pair-bonding primates, Callithrix penicillata.

Authors:  Adam S Smith; Anders Agmo; Andrew K Birnie; Jeffrey A French
Journal:  Horm Behav       Date:  2009-12-16       Impact factor: 3.587

8.  Rethinking schizophrenia.

Authors:  Thomas R Insel
Journal:  Nature       Date:  2010-11-11       Impact factor: 49.962

9.  Effects of oxytocin on empathy, introspective accuracy, and social symptoms in schizophrenia: A 12-week twice-daily randomized controlled trial.

Authors:  Tate Halverson; L Fredrik Jarskog; Cort Pedersen; David Penn
Journal:  Schizophr Res       Date:  2018-09-20       Impact factor: 4.939

Review 10.  The impact of a single administration of intranasal oxytocin on the recognition of basic emotions in humans: a meta-analysis.

Authors:  Sara Shahrestani; Andrew H Kemp; Adam J Guastella
Journal:  Neuropsychopharmacology       Date:  2013-04-10       Impact factor: 7.853
View more
  7 in total

1.  The Role of OXT, OXTR, AVP, and AVPR1a Gene Expression in the Course of Schizophrenia.

Authors:  Marta Broniarczyk-Czarniak; Janusz Szemraj; Janusz Śmigielski; Piotr Gałecki
Journal:  Curr Issues Mol Biol       Date:  2022-01-12       Impact factor: 2.976

Review 2.  Oxytocin in Women's Health and Disease.

Authors:  Ning Liu; Haipeng Yang; Liqun Han; Mingxing Ma
Journal:  Front Endocrinol (Lausanne)       Date:  2022-02-15       Impact factor: 5.555

3.  Molecular Insights in Psychiatry.

Authors:  Giovanna Traina; Jack Adam Tuszynski; Massimo Cocchi
Journal:  Int J Mol Sci       Date:  2022-04-28       Impact factor: 5.923

Review 4.  Crosstalk between Schizophrenia and Metabolic Syndrome: The Role of Oxytocinergic Dysfunction.

Authors:  Kah Kheng Goh; Cynthia Yi-An Chen; Tzu-Hua Wu; Chun-Hsin Chen; Mong-Liang Lu
Journal:  Int J Mol Sci       Date:  2022-06-25       Impact factor: 6.208

Review 5.  Progress and Pitfalls in Developing Agents to Treat Neurocognitive Deficits Associated with Schizophrenia.

Authors:  Tanja Veselinović; Irene Neuner
Journal:  CNS Drugs       Date:  2022-07-13       Impact factor: 6.497

Review 6.  Oxytocin: Narrative Expert Review of Current Perspectives on the Relationship with Other Neurotransmitters and the Impact on the Main Psychiatric Disorders.

Authors:  Tudor Florea; Matei Palimariciuc; Ana Caterina Cristofor; Irina Dobrin; Roxana Chiriță; Magdalena Bîrsan; Romeo Petru Dobrin; Manuela Pădurariu
Journal:  Medicina (Kaunas)       Date:  2022-07-11       Impact factor: 2.948

Review 7.  Vasopressin and Its Analogues: From Natural Hormones to Multitasking Peptides.

Authors:  Mladena Glavaš; Agata Gitlin-Domagalska; Dawid Dębowski; Natalia Ptaszyńska; Anna Łęgowska; Krzysztof Rolka
Journal:  Int J Mol Sci       Date:  2022-03-12       Impact factor: 5.923
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.