| Literature DB >> 33669808 |
Elvira Forte1, Micheal A McLellan1,2, Daniel A Skelly1, Nadia A Rosenthal1,3.
Abstract
Recent technological advances have revolutionized the study of tissue biology and garnered a greater appreciation for tissue complexity. In order to understand cardiac development, heart tissue homeostasis, and the effects of stress and injury on the cardiovascular system, it is essential to characterize the heart at high cellular resolution. Single-cell profiling provides a more precise definition of tissue composition, cell differentiation trajectories, and intercellular communication, compared to classical bulk approaches. Here, we aim to review how recent single-cell multi-omic studies have changed our understanding of cell dynamics during cardiac development, and in the healthy and diseased adult myocardium.Entities:
Keywords: cardiac; development; differentiation; heart; injury; regeneration; scRNAseq; single-cell
Mesh：
Year: 2021 PMID： 33669808 PMCID： PMC7922347 DOI： 10.3390/ijms22042071
Source DB: PubMed Journal: Int J Mol Sci ISSN： 1422-0067 Impact factor: 5.923