| Literature DB >> 33669483 |
Jean Harb1,2,3, Nicolas Mennesson1, Cassandra Lepetit1, Maeva Fourny1, Margaux Louvois1, Adrien Bosseboeuf1, Sophie Allain-Maillet1, Olivier Decaux4, Caroline Moreau5, Anne Tallet6, Eric Piver7,8, Philippe Moreau9, Valéry Salle10, Edith Bigot-Corbel1,3, Sylvie Hermouet1,11.
Abstract
Chronic stimulation by infectious pathogens or self-antigen glucosylsphingosine (GlcSph) can lead to monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM). Novel assays such as the multiplex infectious antigen microarray (MIAA) and GlcSph assays, permit identification of targets for >60% purified monoclonal immunoglobulins (Igs). Searching for additional targets, we selected 28 purified monoclonal Igs whose antigen was not represented on the MIAA and GlcSph assays; their specificity of recognition was then analyzed using microarrays consisting of 3760 B-cell epitopes from 196 pathogens. The peptide sequences PALTAVETG and PALTAAETG of the VP1 coat proteins of human poliovirus 1/3 and coxsackievirus B1/B3, respectively, were specifically recognized by 6/28 monoclonal Igs. Re-analysis of patient cohorts showed that purified monoclonal Igs from 10/155 MGUS/SM (6.5%) and 3/147 MM (2.0%) bound to the PALTAVETG or PALTAAETG epitopes. Altogether, PALTAV/AETG-initiated MGUS are not rare and few seem to evolve toward myeloma.Entities:
Keywords: MGUS; antigen specificity; coxsackievirus; infection; monoclonal gammopathy; monoclonal immunoglobulin; multiple myeloma; pathogen; poliovirus
Year: 2021 PMID： 33669483 DOI： 10.3390/cells10020438
Source DB: PubMed Journal: Cells ISSN： 2073-4409 Impact factor: 6.600