| Literature DB >> 33669111 |
Yibo Fu1, Francesca Ricciardiello2, Gang Yang1, Jiangdong Qiu1, Hua Huang1, Jianchun Xiao1, Zhe Cao1, Fangyu Zhao1, Yueze Liu1, Wenhao Luo1, Guangyu Chen1, Lei You1, Ferdinando Chiaradonna2, Lianfang Zheng3, Taiping Zhang1,4.
Abstract
The first-line chemotherapies for patients with unresectable pancreatic cancer (PC) are 5-fluorouracil (5-FU) and gemcitabine therapy. However, due to chemoresistance the prognosis of patients with PC has not been significantly improved. Mitochondria are essential organelles in eukaryotes that evolved from aerobic bacteria. In recent years, many studies have shown that mitochondria play important roles in tumorigenesis and may act as chemotherapeutic targets in PC. In addition, according to recent studies, mitochondria may play important roles in the chemoresistance of PC by affecting apoptosis, metabolism, mtDNA metabolism, and mitochondrial dynamics. Interfering with some of these factors in mitochondria may improve the sensitivity of PC cells to chemotherapeutic agents, such as gemcitabine, making mitochondria promising targets for overcoming chemoresistance in PC.Entities:
Keywords: apoptosis; chemoresistance; metabolism; mitochondria; pancreatic cancer
Year: 2021 PMID： 33669111 PMCID： PMC7996512 DOI： 10.3390/cells10030497
Source DB: PubMed Journal: Cells ISSN： 2073-4409 Impact factor: 6.600