| Literature DB >> 33668649 |
Tania Henriquez1, Larissa Wirtz1, Dan Su1, Heinrich Jung1.
Abstract
The solute/sodium symporter family (SSS family; TC 2.A.21; SLC5) consists of integral membrane proteins that use an existing sodium gradient to drive the uphill transport of various solutes, such as sugars, amino acids, vitamins, or ions across the membrane. This large family has representatives in all three kingdoms of life. The human sodium/iodide symporter (NIS) and the sodium/glucose transporter (SGLT1) are involved in diseases such as iodide transport defect or glucose-galactose malabsorption. Moreover, the bacterial sodium/proline symporter PutP and the sodium/sialic acid symporter SiaT play important roles in bacteria-host interactions. This review focuses on the physiological significance and structural and functional features of prokaryotic members of the SSS family. Special emphasis will be given to the roles and properties of proteins containing an SSS family domain fused to domains typically found in bacterial sensor kinases.Entities:
Keywords: PutP; SLC5; bacterial sensor kinase; bacterial two-component systems; secondary transport; signal transduction; solute/sodium symport
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Year: 2021 PMID： 33668649 PMCID： PMC7918813 DOI： 10.3390/ijms22041880
Source DB: PubMed Journal: Int J Mol Sci ISSN： 1422-0067 Impact factor: 5.923