Chitosan-based nanocarriers for encapsulation and delivery of curcumin: A review.

To overcome the poor aqueous solubility and bioavailability of curcumin, emphasize its functional features, and broaden its applications in the food and pharmaceutical industries, many nanoscale systems have been widely applied for its encapsulation and delivery. Over many decades, chitosan as a natural biopolymer has been extensively studied due to its polycationic nature, biodegradability, biocompatibility, non-toxicity, and non-allergenic. Various chitosan-based nanocarriers with unique properties for curcumin delivery, including but not limited to, self-assembled nanoparticles, nanocomposites, nanoemulsions, nanotubes, and nanofibers, have been designed. This review focuses on the most-recently reported fabrication techniques of different types of chitosan-based nanocarriers. The functionalities of chitosan in each formulation which determine the physicochemical properties such as surface charge, morphology, encapsulation driving force, and release profile, were discussed in detail. Moreover, the current pharmaceutical applications of curcumin-loaded chitosan nanoparticles were elaborated. The role of chitosan in facilitating the delivery of curcumin and improving the therapeutic effects on many chronic diseases, including cancer, bacterial infection, wound healing, Alzheimer's diseases, inflammatory bowel disease, and hepatitis C virus, were illustrated. Particularly, the recently discovered mechanisms of action of curcumin-loaded chitosan nanoparticles against the abovementioned diseases were highlighted.