| Literature DB >> 33667368 |
William C Hahn1, Joel S Bader2, Theodore P Braun3, Andrea Califano4, Paul A Clemons5, Brian J Druker3, Andrew J Ewald6, Haian Fu7, Subhashini Jagu8, Christopher J Kemp9, William Kim10, Calvin J Kuo11, Michael McManus12, Gordon B Mills13, Xiulei Mo7, Nidhi Sahni14, Stuart L Schreiber5, Jessica A Talamas15, Pablo Tamayo10, Jeffrey W Tyner16, Bridget K Wagner5, William A Weiss17, Daniela S Gerhard8.
Abstract
The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles remains mysterious, and many cancer features transcend their genomes. Consequently, tumor genomic characterization does not influence therapy for most patients. Approaches to understand the function and circuitry of cancer genes provide complementary approaches to elucidate both oncogene and non-oncogene dependencies. Emerging work indicates that the diversity of therapeutic targets engendered by non-oncogene dependencies is much larger than the list of recurrently mutated genes. Here we describe a framework for this expanded list of cancer targets, providing novel opportunities for clinical translation.Entities:
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Year: 2021 PMID： 33667368 PMCID： PMC8066437 DOI： 10.1016/j.cell.2021.02.020
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582