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Literature DB >> 33667358

Lysosomal Regulation of Metabolism in Quiescent Hematopoietic Stem Cells: More than Just Autophagy.

Abstract

The depth of quiescence in hematopoietic stem cells (HSCs) dictates their potency and is sensitive to metabolic perturbations. Recent evidence suggests that lysosomal functions distinct from autophagic processes are pivotal in regulating quiescence versus activation by potential control of the access to a nutrient reservoir required for HSC activation.

Entities: Chemical

Mesh：

Year: 2021 PMID： 33667358 PMCID： PMC8147711 DOI： 10.1016/j.stem.2021.02.017

Source DB: PubMed Journal: Cell Stem Cell ISSN： 1875-9777 Impact factor: 24.633

10 in total

1. Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate.

Authors: Lélia Delamarre; Margit Pack; Henry Chang; Ira Mellman; E Sergio Trombetta
Journal: Science Date: 2005-03-11 Impact factor: 47.728

Review 2. Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing.

Authors: Navdeep S Chandel; Heinrich Jasper; Theodore T Ho; Emmanuelle Passegué
Journal: Nat Cell Biol Date: 2016-07-18 Impact factor: 28.824

3. Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency.

Authors: Raymond Liang; Tasleem Arif; Svetlana Kalmykova; Artem Kasianov; Miao Lin; Vijay Menon; Jiajing Qiu; Jeffrey M Bernitz; Kateri Moore; Fangming Lin; Deanna L Benson; Nikolaos Tzavaras; Milind Mahajan; Dmitri Papatsenko; Saghi Ghaffari
Journal: Cell Stem Cell Date: 2020-02-27 Impact factor: 24.633

4. Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging.

Authors: Dena S Leeman; Katja Hebestreit; Tyson Ruetz; Ashley E Webb; Andrew McKay; Elizabeth A Pollina; Ben W Dulken; Xiaoai Zhao; Robin W Yeo; Theodore T Ho; Salah Mahmoudi; Keerthana Devarajan; Emmanuelle Passegué; Thomas A Rando; Judith Frydman; Anne Brunet
Journal: Science Date: 2018-03-15 Impact factor: 47.728

5. Asymmetric lysosome inheritance predicts activation of haematopoietic stem cells.

Authors: Dirk Loeffler; Arne Wehling; Florin Schneiter; Yang Zhang; Niklas Müller-Bötticher; Philipp S Hoppe; Oliver Hilsenbeck; Konstantinos D Kokkaliaris; Max Endele; Timm Schroeder
Journal: Nature Date: 2019-09-04 Impact factor: 49.962

Review 6. Stem cells and the impact of ROS signaling.

Authors: Carolina L Bigarella; Raymond Liang; Saghi Ghaffari
Journal: Development Date: 2014-11 Impact factor: 6.868

Review 7. Lysosomes as dynamic regulators of cell and organismal homeostasis.

Authors: Andrea Ballabio; Juan S Bonifacino
Journal: Nat Rev Mol Cell Biol Date: 2019-11-25 Impact factor: 94.444

Review 8. The Lysosome as a Regulatory Hub.

Authors: Rushika M Perera; Roberto Zoncu
Journal: Annu Rev Cell Dev Biol Date: 2016-08-03 Impact factor: 11.902

9. Autophagy maintains the metabolism and function of young and old stem cells.

Authors: Theodore T Ho; Matthew R Warr; Emmalee R Adelman; Olivia M Lansinger; Johanna Flach; Evgenia V Verovskaya; Maria E Figueroa; Emmanuelle Passegué
Journal: Nature Date: 2017-03-01 Impact factor: 49.962

10. Enhanced lysosomal degradation maintains the quiescent state of neural stem cells.

Authors: Taeko Kobayashi; Wenhui Piao; Toshiya Takamura; Hiroshi Kori; Hitoshi Miyachi; Satsuki Kitano; Yumiko Iwamoto; Mayumi Yamada; Itaru Imayoshi; Seiji Shioda; Andrea Ballabio; Ryoichiro Kageyama
Journal: Nat Commun Date: 2019-11-29 Impact factor: 14.919

10 in total

3 in total

1. Mitochondrial localization and moderated activity are key to murine erythroid enucleation.

Authors: Raymond Liang; Vijay Menon; Jiajing Qiu; Tasleem Arif; Santosh Renuse; Miao Lin; Roberta Nowak; Boris Hartmann; Nikos Tzavaras; Deanna L Benson; Jerry E Chipuk; Miguel Fribourg; Akhilesh Pandey; Velia Fowler; Saghi Ghaffari
Journal: Blood Adv Date: 2021-05-25

Review 2. Cell Biology Meets Cell Metabolism: Energy Production Is Similar in Stem Cells and in Cancer Stem Cells in Brain and Bone Marrow.

Authors: Cornelis J F van Noorden; Barbara Breznik; Metka Novak; Amber J van Dijck; Saloua Tanan; Miloš Vittori; Urban Bogataj; Noëlle Bakker; Joseph D Khoury; Remco J Molenaar; Vashendriya V V Hira
Journal: J Histochem Cytochem Date: 2021-10-29 Impact factor: 2.479

Review 3. Lysosomes in Stem Cell Quiescence: A Potential Therapeutic Target in Acute Myeloid Leukemia.

Authors: Vaibhav Jain; Swaroop Bose; Awadhesh K Arya; Tasleem Arif
Journal: Cancers (Basel) Date: 2022-03-23 Impact factor: 6.639

3 in total