| Literature DB >> 33665436 |
Ekramy Elmorsy1,2, Eman Elsharkawy3,4, Fahad A Alhumaydhi5, Mohamed Salama1,6.
Abstract
Alzheimer's disease (AD) is the commonest neurodegenerative disorder with a wide array of manifestations, courses, and contributing causes. Despite being clinically characterized a long time ago; no treatment has been developed that could improve the pathology or slow down the disease manifestation- so far. Indian Catechu methanolic extract (ICME) has proved to have multiple beneficial effects that support its use in several disorders- especially those with complex etiology. In the present study, we evaluated the neuroprotective effect of ICME in a rat model of AD using Aluminum Chloride (AlCl3). The results showed that ICME could have a positive impact on the course of AD through its anticholinesterase effect and significant antioxidant effect which was reflected on the animals both on behavioral tests as well as hallmark pathological findings.Entities:
Keywords: Acetyl cholinesterase and neuro-monamines; Alzheimer disease; Beta-amyloid proteins; Indian Catechu; Oxidative stress; Tauopathies
Year: 2021 PMID： 33665436 PMCID： PMC7898000 DOI： 10.1016/j.heliyon.2021.e06269
Source DB: PubMed Journal: Heliyon ISSN： 2405-8440