Literature DB >> 33665159

The tRNA-Derived Fragment-3017A Promotes Metastasis by Inhibiting NELL2 in Human Gastric Cancer.

Linhao Tong1, Weixu Zhang1, Bicheng Qu1, Fei Zhang1, Zhonghua Wu1, Jinxin Shi1, Xiaowan Chen1, Yongxi Song1, Zhenning Wang1.   

Abstract

tRNA-derived fragments (tRFs) are a new classification of small non-coding RNAs (sncRNAs) derived from the specific cleavage of precursors and mature tRNAs. Accumulating recent evidence has shown that tRFs are frequently abnormal in several cancers. Nevertheless, the role of tRFs in gastric cancer and its mechanism remain unclear. In this study, we found abnormal expression of tRF-3017A (derived from tRNA-Val-TAC) in gastric cancer tissues and cell lines and confirmed its effect on promoting the invasion and migration of gastric cancer cells through functional experiments in vitro. Analysis of clinicopathologic data showed patients with higher tRF-3017A were associated with significantly higher lymph node metastasis. Mechanistic investigation implies that tRF-3017A regulates the tumor suppressor gene NELL2 through forming the RNA-induced silencing complex (RISC) with Argonaute (AGO) proteins. In this study, we found that higher tRF-3017A were associated with significantly higher lymph node metastasis in gastric cancer patients and the tRF-3017A may play a role in promoting the migration and invasion of gastric cancer cells by silencing tumor suppressor NELL2.
Copyright © 2021 Tong, Zhang, Qu, Zhang, Wu, Shi, Chen, Song and Wang.

Entities:  

Keywords:  NELL2; gastric cancer; lymph node metastasis; molecular mechanism; tRNA-derived fragment

Year:  2021        PMID： 33665159      PMCID： PMC7921707          DOI： 10.3389/fonc.2020.570916

Source DB:  PubMed          Journal:  Front Oncol        ISSN： 2234-943X            Impact factor:   6.244


  59 in total

1.  Transfer RNA-derived fragments target and regulate ribosome-associated aminoacyl-transfer RNA synthetases.

Authors:  Anna M Mleczko; Piotr Celichowski; Kamilla Bąkowska-Żywicka
Journal:  Biochim Biophys Acta Gene Regul Mech       Date:  2018-06-06       Impact factor: 4.490

Review 2.  Management of gastric cancer in Asia: resource-stratified guidelines.

Authors:  Lin Shen; Yan-Shen Shan; Huang-Ming Hu; Timothy J Price; Bhawna Sirohi; Kun-Huei Yeh; Yi-Hsin Yang; Takeshi Sano; Han-Kwang Yang; Xiaotian Zhang; Sook Ryun Park; Masashi Fujii; Yoon-Koo Kang; Li-Tzong Chen
Journal:  Lancet Oncol       Date:  2013-11       Impact factor: 41.316

Review 3.  Role of the tRNA-Derived Small RNAs in Cancer: New Potential Biomarkers and Target for Therapy.

Authors:  Veronica Balatti; Yuri Pekarsky; Carlo M Croce
Journal:  Adv Cancer Res       Date:  2017-08-10       Impact factor: 6.242

4.  Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.

Authors:  Freddie Bray; Jacques Ferlay; Isabelle Soerjomataram; Rebecca L Siegel; Lindsey A Torre; Ahmedin Jemal
Journal:  CA Cancer J Clin       Date:  2018-09-12       Impact factor: 508.702

5.  Endogenous tRNA-Derived Fragments Suppress Breast Cancer Progression via YBX1 Displacement.

Authors:  Hani Goodarzi; Xuhang Liu; Hoang C B Nguyen; Steven Zhang; Lisa Fish; Sohail F Tavazoie
Journal:  Cell       Date:  2015-05-07       Impact factor: 41.582

6.  Identification of aberrant tRNA-halves expression patterns in clear cell renal cell carcinoma.

Authors:  Malin Nientiedt; Mario Deng; Doris Schmidt; Sven Perner; Stefan C Müller; Jörg Ellinger
Journal:  Sci Rep       Date:  2016-11-24       Impact factor: 4.379

Review 7.  tRNA-Derived Small RNAs: Biogenesis, Modification, Function and Potential Impact on Human Disease Development.

Authors:  Vera Oberbauer; Matthias R Schaefer
Journal:  Genes (Basel)       Date:  2018-12-05       Impact factor: 4.096

8.  Pathological significance of tRNA-derived small RNAs in neurological disorders.

Authors:  Chuan Qin; Pei-Pei Xu; Xin Zhang; Chao Zhang; Chang-Bin Liu; De-Gang Yang; Feng Gao; Ming-Liang Yang; Liang-Jie Du; Jian-Jun Li
Journal:  Neural Regen Res       Date:  2020-02       Impact factor: 5.135

9.  Description of plant tRNA-derived RNA fragments (tRFs) associated with argonaute and identification of their putative targets.

Authors:  Guilherme Loss-Morais; Peter M Waterhouse; Rogerio Margis
Journal:  Biol Direct       Date:  2013-02-12       Impact factor: 4.540

10.  Modulation of gene expression by human cytosolic tRNase Z(L) through 5'-half-tRNA.

Authors:  Reyad A Elbarbary; Hiroaki Takaku; Naoto Uchiumi; Hiroko Tamiya; Mayumi Abe; Masayuki Takahashi; Hiroshi Nishida; Masayuki Nashimoto
Journal:  PLoS One       Date:  2009-06-15       Impact factor: 3.240
View more
  16 in total

Review 1.  tRNA-derived fragments (tRFs) in cancer.

Authors:  Yuri Pekarsky; Veronica Balatti; Carlo M Croce
Journal:  J Cell Commun Signal       Date:  2022-08-29       Impact factor: 5.908

2.  Serum transfer RNA-derived fragment tRF-31-79MP9P9NH57SD acts as a novel diagnostic biomarker for non-small cell lung cancer.

Authors:  Jipeng Li; Chao Cao; Laifu Fang; Wanjun Yu
Journal:  J Clin Lab Anal       Date:  2022-05-16       Impact factor: 3.124

3.  Evaluation of serum tRF-23-Q99P9P9NDD as a potential biomarker for the clinical diagnosis of gastric cancer.

Authors:  Yu Zhang; Xinliang Gu; Xinyue Qin; Yuejiao Huang; Shaoqing Ju
Journal:  Mol Med       Date:  2022-06-11       Impact factor: 6.376

Review 4.  Transfer RNA-derived small RNA: an emerging small non-coding RNA with key roles in cancer.

Authors:  Xinliang Gu; Yu Zhang; Xinyue Qin; Shuo Ma; Yuejiao Huang; Shaoqing Ju
Journal:  Exp Hematol Oncol       Date:  2022-06-03

5.  tRNA-derived fragment TRF365 regulates the metabolism of anterior cruciate ligament cells by targeting IKBKB.

Authors:  Dianbo Long; Yiyang Xu; Guping Mao; Ruobing Xin; Zengfa Deng; Hongyi Liao; Zhiwen Li; Zhi Yang; Baoxi Yu; Zhijian Yang; Aishan He; Ziji Zhang; Yan Kang
Journal:  Cell Death Discov       Date:  2022-01-10

6.  Elucidating the Role of Serum tRF-31-U5YKFN8DYDZDD as a Novel Diagnostic Biomarker in Gastric Cancer (GC).

Authors:  Yuejiao Huang; Haiyan Zhang; Xinliang Gu; Shiyi Qin; Ming Zheng; Xiangrong Shi; Chunlei Peng; Shaoqing Ju
Journal:  Front Oncol       Date:  2021-08-23       Impact factor: 6.244

7.  The tRNA-Derived Fragment tRF-24-V29K9UV3IU Functions as a miRNA-like RNA to Prevent Gastric Cancer Progression by Inhibiting GPR78 Expression.

Authors:  Hui Wang; Weikang Huang; Xirui Fan; Xiaoxue He; Sijin Chen; Su Yu; Yan Zhang
Journal:  J Oncol       Date:  2022-04-29       Impact factor: 4.375

8.  A 5`-tRNA Derived Fragment NamedtiRNA-Val-CAC-001 Works as a Suppressor in Gastric Cancer.

Authors:  Junyu Zheng; Cong Li; Zining Zhu; Fengming Yang; Xiaoming Wang; Pan Jiang; Feng Yan
Journal:  Cancer Manag Res       Date:  2022-08-04       Impact factor: 3.602

9.  Serum hsa_tsr016141 as a Kind of tRNA-Derived Fragments Is a Novel Biomarker in Gastric Cancer.

Authors:  Xinliang Gu; Shuo Ma; Bo Liang; Shaoqing Ju
Journal:  Front Oncol       Date:  2021-05-13       Impact factor: 6.244

Review 10.  Extracellular vesicles-associated tRNA-derived fragments (tRFs): biogenesis, biological functions, and their role as potential biomarkers in human diseases.

Authors:  Qiuyan Weng; Yao Wang; Yaoyao Xie; Xiuchong Yu; Shuangshuang Zhang; Jiaxin Ge; Zhe Li; Guoliang Ye; Junming Guo
Journal:  J Mol Med (Berl)       Date:  2022-03-24       Impact factor: 5.606
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.