Mei-Yun Wu1,2, Sheng-Chih Kuo3, Su-Fen Chuang4, Cheng-Hsi Yeh3, Shih-Min Yin3, Wei-Feng Li3, Hung-Jen Wang5, Chao-Long Chen3, Chih-Chi Wang3, Chih-Che Lin3. 1. College of Nursing, Kaohsiung Medical University, Kaohsiung, Taiwan. 2. Department of Nursing, Chang Gung Memorial Hospital, Kaohsiung, Taiwan. 3. Department of Surgery, Chang Gung Memorial Hospital, Kaohsiung, Taiwan. 4. Dietitian, Department of Nutritional, Chang Gung Memorial Hospital, Kaohsiung, Taiwan. 5. Department of Urology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Abstract
BACKGROUND: Liver transplantation (LT) is one of the widely recognised and leading treatments for end-stage liver disease. Nutrition impacts its success. Total parenteral nutrition (TPN) is usually prescribed for patients recommended prolonged fasting after LT. The supplement of SMOFlipid (soybean oil, MCT oil, olive oil, and fish oil) is easily metabolised to produce energy, and it possesses anti-inflammatory effects; however, SMOFlipid emulsion use raises concerns regarding coagulopathy after LT. This study investigated the postoperative correlation between SMOFlipid and coagulation in LT. MATERIALS AND METHODS: The medical records of 54 recipients of living donor LT between January 2012 and June 2015 were retrospectively reviewed. Patients with pretransplant platelet count <40,000/μL and >40,000/μL were assigned to the non-SMOFlipid (n = 23) group and the SMOFlipid (n = 31) group, respectively. RESULTS: The coagulation and nutrition profile of patients improved significantly after TPN support. No significant difference was observed in the coagulation profile between SMOFlipid and non-SMOFlipid groups. Although the SMOFlipid group exhibited a higher platelet count than the non-SMOFlipid group on day 7 (P < 0.001), no significant differences were observed in the platelet count on 14 and 30 days after TPN support between the 2 groups. CONCLUSION: TPN using SMOFlipid after LT is a good strategy for improving nutritional status without increasing the risks of bleeding and coagulation in patients intolerant of early enteral nutrition. Moreover, SMOFlipid use may not cause coagulopathy up to 14 days after LT. Overall, SMOFlipid provides nutritional benefits without increasing the risk of bleeding.
BACKGROUND: Liver transplantation (LT) is one of the widely recognised and leading treatments for end-stage liver disease. Nutrition impacts its success. Total parenteral nutrition (TPN) is usually prescribed for patients recommended prolonged fasting after LT. The supplement of SMOFlipid (soybean oil, MCT oil, olive oil, and fish oil) is easily metabolised to produce energy, and it possesses anti-inflammatory effects; however, SMOFlipid emulsion use raises concerns regarding coagulopathy after LT. This study investigated the postoperative correlation between SMOFlipid and coagulation in LT. MATERIALS AND METHODS: The medical records of 54 recipients of living donor LT between January 2012 and June 2015 were retrospectively reviewed. Patients with pretransplant platelet count <40,000/μL and >40,000/μL were assigned to the non-SMOFlipid (n = 23) group and the SMOFlipid (n = 31) group, respectively. RESULTS: The coagulation and nutrition profile of patients improved significantly after TPN support. No significant difference was observed in the coagulation profile between SMOFlipid and non-SMOFlipid groups. Although the SMOFlipid group exhibited a higher platelet count than the non-SMOFlipid group on day 7 (P < 0.001), no significant differences were observed in the platelet count on 14 and 30 days after TPN support between the 2 groups. CONCLUSION: TPN using SMOFlipid after LT is a good strategy for improving nutritional status without increasing the risks of bleeding and coagulation in patients intolerant of early enteral nutrition. Moreover, SMOFlipid use may not cause coagulopathy up to 14 days after LT. Overall, SMOFlipid provides nutritional benefits without increasing the risk of bleeding.
Authors: Pierre Singer; Mette M Berger; Greet Van den Berghe; Gianni Biolo; Philip Calder; Alastair Forbes; Richard Griffiths; Georg Kreyman; Xavier Leverve; Claude Pichard Journal: Clin Nutr Date: 2009-06-07 Impact factor: 7.324