| Literature DB >> 33664226 |
Sally Grace1, Maria Gloria Rossetti2,3, Nicholas Allen4,5, Albert Batalla6, Marcella Bellani2, Paolo Brambilla3,7, Yann Chye8, Janna Cousijn9, Anna E Goudriaan10, Robert Hester5, Kent Hutchison11, Izelle Labuschagne1, Reza Momenan12, Rocio Martin-Santos13, Peter Rendell1, Nadia Solowij14, Rajita Sinha15, Chiang-Shan Ray Li15, Lianne Schmaal16,17, Zsuzsika Sjoerds18, Chao Suo8, Gill Terrett1, Ruth J van Holst10, Dick J Veltman9, Murat Yücel8, Paul Thompson19, Patricia Conrod20, Scott Mackey21, Hugh Garavan21, Valentina Lorenzetti22.
Abstract
Males and females with alcohol dependence have distinct mental health and cognitive problems. Animal models of addiction postulate that the underlying neurobiological mechanisms are partially distinct, but there is little evidence of sex differences in humans with alcohol dependence as most neuroimaging studies have been conducted in males. We examined hippocampal and amygdala subregions in a large sample of 966 people from the ENIGMA Addiction Working Group. This comprised 643 people with alcohol dependence (225 females), and a comparison group of 323 people without alcohol dependence (98 females). Males with alcohol dependence had smaller volumes of the total amygdala and its basolateral nucleus than male controls, that exacerbated with alcohol dose. Alcohol dependence was also associated with smaller volumes of the hippocampus and its CA1 and subiculum subfield volumes in both males and females. In summary, hippocampal and amygdalar subregions may be sensitive to both shared and distinct mechanisms in alcohol-dependent males and females.Entities:
Mesh：
Year: 2021 PMID： 33664226 PMCID： PMC7933136 DOI： 10.1038/s41398-021-01204-1
Source DB: PubMed Journal: Transl Psychiatry ISSN： 2158-3188 Impact factor: 6.222