Literature DB >> 33663512

Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses.

Ming-Hsiang Hong1, I-Chun Weng1, Fang-Yen Li1, Wei-Han Lin1, Fu-Tong Liu2.   

Abstract

Galectins are animal lectins that recognize carbohydrates and play important roles in maintaining cellular homeostasis. Recent studies have indicated that under a variety of challenges, intracellular galectins bind to host glycans displayed on damaged endocytic vesicles and accumulate around these damaged organelles. Accumulated galectins then engage cellular proteins and subsequently control cellular responses, such as autophagy. In this review, we have summarized the stimuli that lead to the accumulation of galectins, the molecular mechanisms of galectin accumulation, and galectin-mediated cellular responses, and elaborate on the differential regulatory effects among galectins.

Entities:  

Keywords:  Autophagy; Carbohydrates; Galectin; Glycans; Infection

Year:  2021        PMID： 33663512      PMCID： PMC7931364          DOI： 10.1186/s12929-021-00713-x

Source DB:  PubMed          Journal:  J Biomed Sci        ISSN： 1021-7770            Impact factor:   8.410


  44 in total

1.  Association of a macrophage galactoside-binding protein with Mycobacterium-containing phagosomes.

Authors:  Wandy L Beatty; Elizabeth R Rhoades; Daniel K Hsu; Fu-Tong Liu; David G Russell
Journal:  Cell Microbiol       Date:  2002-03       Impact factor: 3.715

2.  Intracellular galectins control cellular responses commensurate with cell surface carbohydrate composition.

Authors:  Ming-Hsiang Hong; Wei-Han Lin; I-Chun Weng; Yu-Hsien Hung; Hung-Lin Chen; Huan-Yuan Chen; Peilin Chen; Chun-Hung Lin; Wei Yuan Yang; Fu-Tong Liu
Journal:  Glycobiology       Date:  2019-12-12       Impact factor: 4.313

Review 3.  Intracellular galectins in cancer cells: potential new targets for therapy (Review).

Authors:  Maria C Vladoiu; Marilyne Labrie; Yves St-Pierre
Journal:  Int J Oncol       Date:  2014-01-21       Impact factor: 5.650

4.  Mechanism of Enhanced Cellular Uptake and Cytosolic Retention of MK2 Inhibitory Peptide Nano-polyplexes.

Authors:  Kameron V Kilchrist; Brian C Evans; Colleen M Brophy; Craig L Duvall
Journal:  Cell Mol Bioeng       Date:  2016-06-06       Impact factor: 2.321

5.  Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown.

Authors:  Anders Wittrup; Angela Ai; Xing Liu; Peter Hamar; Radiana Trifonova; Klaus Charisse; Muthiah Manoharan; Tomas Kirchhausen; Judy Lieberman
Journal:  Nat Biotechnol       Date:  2015-07-20       Impact factor: 54.908

6.  TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis.

Authors:  Santosh Chauhan; Suresh Kumar; Ashish Jain; Marisa Ponpuak; Michal H Mudd; Tomonori Kimura; Seong Won Choi; Ryan Peters; Michael Mandell; Jack-Ansgar Bruun; Terje Johansen; Vojo Deretic
Journal:  Dev Cell       Date:  2016-09-29       Impact factor: 12.270

7.  The animal lectin galectin-3 interacts with bacterial lipopolysaccharides via two independent sites.

Authors:  A Mey; H Leffler; Z Hmama; G Normier; J P Revillard
Journal:  J Immunol       Date:  1996-02-15       Impact factor: 5.422

8.  Galectin-3 Inhibits Galectin-8/Parkin-Mediated Ubiquitination of Group A Streptococcus.

Authors:  Yi-Lin Cheng; Yan-Wei Wu; Chih-Feng Kuo; Shiou-Ling Lu; Fu-Tong Liu; Robert Anderson; Chiou-Feng Lin; Yi-Ling Liu; Wan-Yu Wang; Ying-Da Chen; Po-Xing Zheng; Jiunn-Jong Wu; Yee-Shin Lin
Journal:  mBio       Date:  2017-07-25       Impact factor: 7.867

9.  Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion.

Authors:  Teresa L M Thurston; Michal P Wandel; Natalia von Muhlinen; Agnes Foeglein; Felix Randow
Journal:  Nature       Date:  2012-01-15       Impact factor: 49.962

10.  Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis.

Authors:  David Freeman; Rudy Cedillos; Samantha Choyke; Zana Lukic; Kathleen McGuire; Shauna Marvin; Andrew M Burrage; Stacey Sudholt; Ajay Rana; Christopher O'Connor; Christopher M Wiethoff; Edward M Campbell
Journal:  PLoS One       Date:  2013-04-25       Impact factor: 3.240
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  6 in total

1.  Macrophages target Listeria monocytogenes by two discrete non-canonical autophagy pathways.

Authors:  Alexander Gluschko; Alina Farid; Marc Herb; Daniela Grumme; Martin Krönke; Michael Schramm
Journal:  Autophagy       Date:  2021-09-05       Impact factor: 13.391

2.  A patatin-like phospholipase mediates Rickettsia parkeri escape from host membranes.

Authors:  Gina M Borgo; Thomas P Burke; Cuong J Tran; Nicholas T N Lo; Patrik Engström; Matthew D Welch
Journal:  Nat Commun       Date:  2022-06-27       Impact factor: 17.694

Review 3.  What is the Sugar Code?

Authors:  Hans-Joachim Gabius; Maré Cudic; Tammo Diercks; Herbert Kaltner; Jürgen Kopitz; Kevin H Mayo; Paul V Murphy; Stefan Oscarson; René Roy; Andreas Schedlbauer; Stefan Toegel; Antonio Romero
Journal:  Chembiochem       Date:  2021-09-22       Impact factor: 3.461

Review 4.  Unraveling How Tumor-Derived Galectins Contribute to Anti-Cancer Immunity Failure.

Authors:  Diego José Laderach; Daniel Compagno
Journal:  Cancers (Basel)       Date:  2021-09-09       Impact factor: 6.575

Review 5.  Galectins as potential therapeutic targets in STIs in the female genital tract.

Authors:  Agustin L Lujan; Diego O Croci; Gabriel A Rabinovich; Maria T Damiani
Journal:  Nat Rev Urol       Date:  2022-02-01       Impact factor: 14.432

Review 6.  Medawar's PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation.

Authors:  Ellen Menkhorst; Nandor Gabor Than; Udo Jeschke; Gabriela Barrientos; Laszlo Szereday; Gabriela Dveksler; Sandra M Blois
Journal:  Front Immunol       Date:  2021-12-15       Impact factor: 7.561
  6 in total

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