Hee Won Yang1, Jong Bin Bae2,3, Jung-Im Na4, Ki Woong Kim1,5,6. 1. Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea. 2. Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea. jongbinbae@hotmail.com. 3. Department of Psychiatry, Seoul National University, College of Medicine, Seoul, South Korea. jongbinbae@hotmail.com. 4. Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, South Korea. 5. Department of Psychiatry, Seoul National University, College of Medicine, Seoul, South Korea. 6. Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea.
Abstract
BACKGROUND: Lichenoid drug eruption is rare and can mimic idiopathic lichen planus and other dermatoses. Clonazepam, a commonly used drug for the treatment of anxiety-related disorders and seizures, is known to be an unlikely cause of cutaneous adverse effects. Only one case report of LDE due to clonazepam has been reported. CASE PRESENTATION: A 81-year-old male patient with Alzheimer's disease developed a lichenoid eruption after taking clonazepam. He developed a violaceous scaly patch on his lower extremities, from both buttocks to the feet. The cutaneous eruption resolved 2 months after cessation of clonazepam and with initiation of corticosteroid therapy. CONCLUSION: A skin eruption that develops after clonazepam administration can be a lichenoid drug eruption, which is less likely to resolve spontaneously and requires discontinuation of clonazepam administration.
BACKGROUND:Lichenoid drug eruption is rare and can mimic idiopathic lichen planus and other dermatoses. Clonazepam, a commonly used drug for the treatment of anxiety-related disorders and seizures, is known to be an unlikely cause of cutaneous adverse effects. Only one case report of LDE due to clonazepam has been reported. CASE PRESENTATION: A 81-year-old male patient with Alzheimer's disease developed a lichenoid eruption after taking clonazepam. He developed a violaceous scaly patch on his lower extremities, from both buttocks to the feet. The cutaneous eruption resolved 2 months after cessation of clonazepam and with initiation of corticosteroid therapy. CONCLUSION: A skin eruption that develops after clonazepam administration can be a lichenoid drug eruption, which is less likely to resolve spontaneously and requires discontinuation of clonazepam administration.
Entities:
Keywords:
Clonazepam; Cutaneous; Drug eruption; Lichenoid
Authors: C A Naranjo; U Busto; E M Sellers; P Sandor; I Ruiz; E A Roberts; E Janecek; C Domecq; D J Greenblatt Journal: Clin Pharmacol Ther Date: 1981-08 Impact factor: 6.875
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