Literature DB >> 33662288

Treatment of relapsed and refractory multiple myeloma: recommendations from the International Myeloma Working Group.

Philippe Moreau1, Shaji K Kumar2, Jesús San Miguel3, Faith Davies4, Elena Zamagni5, Nizar Bahlis6, Heinz Ludwig7, Joseph Mikhael8, Evangelos Terpos9, Fredrik Schjesvold10, Thomas Martin11, Kwee Yong12, Brian G M Durie13, Thierry Facon14, Artur Jurczyszyn15, Surbhi Sidana16, Noopur Raje17, Niels van de Donk18, Sagar Lonial19, Michele Cavo5, Sigurdur Y Kristinsson20, Suzanne Lentzsch21, Roman Hajek22, Kenneth C Anderson23, Cristina João24, Hermann Einsele25, Pieter Sonneveld26, Monika Engelhardt27, Rafael Fonseca28, Annette Vangsted29, Katja Weisel30, Rachid Baz31, Vania Hungria32, Jesus G Berdeja33, Fernando Leal da Costa34, Angelo Maiolino35, Anders Waage36, David H Vesole37, Enrique M Ocio38, Hang Quach39, Christoph Driessen40, Joan Bladé41, Xavier Leleu42, Eloisa Riva43, Peter Leif Bergsagel28, Jian Hou44, Wee Joo Chng45, Ulf-Henrik Mellqvist46, Dominik Dytfeld47, Jean-Luc Harousseau48, Hartmut Goldschmidt49, Jacob Laubach23, Nikhil C Munshi23, Francesca Gay50, Meral Beksac51, Luciano J Costa52, Martin Kaiser53, Parameswaran Hari54, Mario Boccadoro50, Saad Z Usmani52, Sonja Zweegman18, Sarah Holstein55, Orhan Sezer56, Simon Harrison57, Hareth Nahi58, Gordon Cook59, Maria-Victoria Mateos60, S Vincent Rajkumar2, Meletios A Dimopoulos9, Paul G Richardson23.   

Abstract

This Policy Review presents the International Myeloma Working Group's clinical practice recommendations for the treatment of relapsed and refractory multiple myeloma. Based on the results of phase 2 and phase 3 trials, these recommendations are proposed for the treatment of patients with relapsed and refractory disease who have received one previous line of therapy, and for patients with relapsed and refractory multiple myeloma who have received two or more previous lines of therapy. These recommendations integrate the issue of drug access in both low-income and middle-income countries and in high-income countries to help guide real-world practice and thus improve patient outcomes.
Copyright © 2021 Elsevier Ltd. All rights reserved.

Entities:  

Year:  2021        PMID: 33662288     DOI: 10.1016/S1470-2045(20)30756-7

Source DB:  PubMed          Journal:  Lancet Oncol        ISSN: 1470-2045            Impact factor:   41.316


  22 in total

1.  Development of a T cell-redirecting bispecific antibody targeting B-cell maturation antigen for the suppression of multiple myeloma cell growth.

Authors:  Jianxin Huo; Yuhan Huang; Ziying Zheng; Xin Ni Tay; Farouq Bin Mahfut; Wei Zhang; Kong-Peng Lam; Yuansheng Yang; Shengli Xu
Journal:  Antib Ther       Date:  2022-06-09

Review 2.  Management of Multiple Myeloma in the Middle East: Unmet Needs, Challenges and Perspective.

Authors:  Ahmad Ibrahim; Nabil Chamseddine; Jean El-Cheikh; Colette Hanna; Walid Moukadem; Fady Nasr; Ahmad Younis; Ali Bazarbachi
Journal:  Clin Hematol Int       Date:  2022-08-30

3.  Multiple myeloma: 2022 update on diagnosis, risk stratification, and management.

Authors:  S Vincent Rajkumar
Journal:  Am J Hematol       Date:  2022-05-23       Impact factor: 13.265

4.  Mechanism of Targeting the Hedgehog Signaling Pathway against Chemotherapeutic Resistance in Multiple Myeloma.

Authors:  Yuefeng Zhang; Guoli Yao; Xinxin Yang; Tao Qiu; Sheng Wang
Journal:  J Oncol       Date:  2022-06-29       Impact factor: 4.501

Review 5.  Gaps and opportunities in the treatment of relapsed-refractory multiple myeloma: Consensus recommendations of the NCI Multiple Myeloma Steering Committee.

Authors:  Shaji Kumar; Lawrence Baizer; Natalie S Callander; Sergio A Giralt; Jens Hillengass; Boris Freidlin; Antje Hoering; Paul G Richardson; Elena I Schwartz; Anthony Reiman; Suzanne Lentzsch; Philip L McCarthy; Sundar Jagannath; Andrew J Yee; Richard F Little; Noopur S Raje
Journal:  Blood Cancer J       Date:  2022-06-29       Impact factor: 9.812

6.  Four-year follow-up of LCAR-B38M in relapsed or refractory multiple myeloma: a phase 1, single-arm, open-label, multicenter study in China (LEGEND-2).

Authors:  Wan-Hong Zhao; Bai-Yan Wang; Li-Juan Chen; Wei-Jun Fu; Jie Xu; Jie Liu; Shi-Wei Jin; Yin-Xia Chen; Xing-Mei Cao; Yun Yang; Yi-Lin Zhang; Fang-Xia Wang; Peng-Yu Zhang; Bo Lei; Liu-Fang Gu; Jian-Li Wang; Hui Zhang; Ju Bai; Yan Xu; Han Zhu; Juan Du; Hua Jiang; Xiao-Hu Fan; Jian-Yong Li; Jian Hou; Zhu Chen; Wang-Gang Zhang; Jian-Qing Mi; Sai-Juan Chen; Ai-Li He
Journal:  J Hematol Oncol       Date:  2022-07-06       Impact factor: 23.168

7.  CT-derived relationship between low relative muscle mass and bone damage in patients with multiple myeloma undergoing stem cells transplantation.

Authors:  Alberto Stefano Tagliafico; Federica Rossi; Bianca Bignotti; Lorenzo Torri; Alessandro Bonsignore; Liliana Belgioia; Alida Domineitto
Journal:  Br J Radiol       Date:  2021-12-21       Impact factor: 3.629

Review 8.  Patients With Multiple Myeloma or Monoclonal Gammopathy of Undetermined Significance.

Authors:  Vanessa Piechotta; Nicole Skoetz; Monika Engelhardt; Hermann Einsele; Hartmut Goldschmidt; Christof Scheid
Journal:  Dtsch Arztebl Int       Date:  2022-04-08       Impact factor: 8.251

9.  Oral ixazomib-dexamethasone vs oral pomalidomide-dexamethasone for lenalidomide-refractory, proteasome inhibitor-exposed multiple myeloma: a randomized Phase 2 trial.

Authors:  Meletios A Dimopoulos; Fredrik Schjesvold; Vadim Doronin; Olga Vinogradova; Hang Quach; Xavier Leleu; Yolanda Gonzalez Montes; Karthik Ramasamy; Alessandra Pompa; Mark-David Levin; Cindy Lee; Ulf Henrik Mellqvist; Roland Fenk; Hélène Demarquette; Hamdi Sati; Alexander Vorog; Richard Labotka; Jichang Du; Mohamed Darif; Shaji Kumar
Journal:  Blood Cancer J       Date:  2022-01-24       Impact factor: 11.037

10.  Pentraxin 3 Inhibits the Angiogenic Potential of Multiple Myeloma Cells.

Authors:  Roberto Ronca; Sara Taranto; Michela Corsini; Chiara Tobia; Cosetta Ravelli; Sara Rezzola; Mirella Belleri; Floriana De Cillis; Annamaria Cattaneo; Marco Presta; Arianna Giacomini
Journal:  Cancers (Basel)       Date:  2021-05-08       Impact factor: 6.639

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