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Literature DB >> 33662259

Cryo-EM catalyzes the exploration of drug selectivity: The CDK7 inhibitor example.

Montserrat Samsó¹.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 2021 PMID： 33662259 PMCID： PMC8105707 DOI： 10.1016/j.bpj.2021.02.010

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

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References

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9 in total

1. TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II.

Authors: Kira Glover-Cutter; Stéphane Larochelle; Benjamin Erickson; Chao Zhang; Kevan Shokat; Robert P Fisher; David L Bentley
Journal: Mol Cell Biol Date: 2009-08-10 Impact factor: 4.272

2. Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study.

Authors: Pascale Hazel; Sebastian H B Kroll; Alexander Bondke; Marion Barbazanges; Hetal Patel; Matthew J Fuchter; R Charles Coombes; Simak Ali; Anthony G M Barrett; Paul S Freemont
Journal: ChemMedChem Date: 2017-02-06 Impact factor: 3.466

3. ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment.

Authors: Hetal Patel; Manikandan Periyasamy; Georgina P Sava; Alexander Bondke; Brian W Slafer; Sebastian H B Kroll; Marion Barbazanges; Richard Starkey; Silvia Ottaviani; Alison Harrod; Eric O Aboagye; Laki Buluwela; Matthew J Fuchter; Anthony G M Barrett; R Charles Coombes; Simak Ali
Journal: Mol Cancer Ther Date: 2018-03-15 Impact factor: 6.261

Review 4. Single-particle cryo-EM-How did it get here and where will it go.

Authors: Yifan Cheng
Journal: Science Date: 2018-08-31 Impact factor: 47.728

Review 5. CDK7 inhibitors as anticancer drugs.

Authors: Georgina P Sava; Hailing Fan; R Charles Coombes; Lakjaya Buluwela; Simak Ali
Journal: Cancer Metastasis Rev Date: 2020-09 Impact factor: 9.264

Cryo-EM catalyzes the exploration of drug selectivity: The CDK7 inhibitor example.

1. TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II.

2. Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study.

3. ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment.

Review 4. Single-particle cryo-EM-How did it get here and where will it go.

Review 5. CDK7 inhibitors as anticancer drugs.

6. Recognition of Cdk2 by Cdk7.

7. Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II.

8. The cryoelectron microscopy structure of the human CDK-activating kinase.

9. 2.5 Å-resolution structure of human CDK-activating kinase bound to the clinical inhibitor ICEC0942.