W-X Li1, W Xu, C-L Huang, L Fei, X-D Xie, Q Li, L Chen. 1. Department of Liver Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China. liqiang66601@163.com.
Abstract
OBJECTIVE: To determine the incidence and risk factors for acute cardiac injury (ACI) and acute kidney injury (AKI), and then investigate their effect on severity and mortality in patients with COVID-19. PATIENTS AND METHODS: A total of 1249 patients with COVID-19 were included in this retrospective study. Predictors of ACI and AKI were investigated. Multivariable-logistic regression models were used to determine the association of ACI (or AKI) with severity and mortality. RESULTS: Median age of patients was 36 years and 61.9% were male. ACI and AKI were observed in 53 (4.2%) and 91 (7.3%) of patients, respectively. Patients with age > 60 years, chronic heart disease, decreased lymphocyte and increased CRP, PCT, and ESR on hospital admission, and Lopinavir/Ritonavir use showed higher odds of ACI. Patients with age > 60 years, male, obesity, hypertension, chronic kidney disease, decreased lymphocyte and increased CRP, PCT, and ESR on hospital admission showed higher odds of AKI. Increased Hs-cTnI (> 300 ng/L), Pro-BNP (> 2500 pg/ml) and decreased e-GFR (< 60 ml/min) revealed higher adjusted mortality. CONCLUSIONS: ACI and AKI were not common in COVID-19 patients in Shanghai, China. However, patients with ACI/AKI had higher severity-rate and mortality-rate when compared to those without ACI/AKI.
OBJECTIVE: To determine the incidence and risk factors for acute cardiac injury (ACI) and acute kidney injury (AKI), and then investigate their effect on severity and mortality in patients with COVID-19. PATIENTS AND METHODS: A total of 1249 patients with COVID-19 were included in this retrospective study. Predictors of ACI and AKI were investigated. Multivariable-logistic regression models were used to determine the association of ACI (or AKI) with severity and mortality. RESULTS: Median age of patients was 36 years and 61.9% were male. ACI and AKI were observed in 53 (4.2%) and 91 (7.3%) of patients, respectively. Patients with age > 60 years, chronic heart disease, decreased lymphocyte and increased CRP, PCT, and ESR on hospital admission, and Lopinavir/Ritonavir use showed higher odds of ACI. Patients with age > 60 years, male, obesity, hypertension, chronic kidney disease, decreased lymphocyte and increased CRP, PCT, and ESR on hospital admission showed higher odds of AKI. Increased Hs-cTnI (> 300 ng/L), Pro-BNP (> 2500 pg/ml) and decreased e-GFR (< 60 ml/min) revealed higher adjusted mortality. CONCLUSIONS: ACI and AKI were not common in COVID-19patients in Shanghai, China. However, patients with ACI/AKI had higher severity-rate and mortality-rate when compared to those without ACI/AKI.
Authors: Michael Y Henein; Giulia Elena Mandoli; Maria Concetta Pastore; Nicolò Ghionzoli; Fouhad Hasson; Muhammad K Nisar; Mohammed Islam; Francesco Bandera; Massimiliano M Marrocco-Trischitta; Irene Baroni; Alessandro Malagoli; Luca Rossi; Andrea Biagi; Rodolfo Citro; Michele Ciccarelli; Angelo Silverio; Giulia Biagioni; Joseph A Moutiris; Federico Vancheri; Giovanni Mazzola; Giulio Geraci; Liza Thomas; Mikhail Altman; John Pernow; Mona Ahmed; Ciro Santoro; Roberta Esposito; Guillem Casas; Rubén Fernández-Galera; Maribel Gonzalez; Jose Rodriguez Palomares; Ibadete Bytyçi; Frank Lloyd Dini; Paolo Cameli; Federico Franchi; Gani Bajraktari; Luigi Paolo Badano; Matteo Cameli Journal: J Clin Med Date: 2021-12-14 Impact factor: 4.241