Mahamadou Niare1,2,3,4, Jacques Desrousseaux5,6, Clarissa Cavandoli7,5, Victor Virak7,5, Oumar Sacko7,5, Saloua Charni7,5,8, Franck-Emmanuel Roux7,5,8. 1. Pôle Neuroscience (Neurochirurgie), Centre Hospitalo-Universitaires de Toulouse, Université de Toulouse, Toulouse, France. mniare@hotmail.com. 2. UPS (Université Paul Sabatier), Toulouse, France. mniare@hotmail.com. 3. Centre de Recherche Cerveau et Cognition (CNRS; CerCo), Toulouse, France. mniare@hotmail.com. 4. Service de Neurochirurgie et CNRS (CERCO), Hôpital Pierre-Paul Riquet, F-31059, Toulouse, France. mniare@hotmail.com. 5. UPS (Université Paul Sabatier), Toulouse, France. 6. Service de Radiothérapie, Institut Universitaire du Cancer, Toulouse, France. 7. Pôle Neuroscience (Neurochirurgie), Centre Hospitalo-Universitaires de Toulouse, Université de Toulouse, Toulouse, France. 8. Centre de Recherche Cerveau et Cognition (CNRS; CerCo), Toulouse, France.
Abstract
OBJECTIVE: To evaluate the role and possible complications of tumor resection in the management of glioblastoma (GBM) in a series of patients 80 years of age and older with review of literature. METHODS: The authors retrospectively analyzed cases involving patients 80 years or older who underwent biopsy or initial resection of GBM at their hospital between 2007 and 2018. A total of 117 patients (mean age 82 years) met the inclusion criteria; 57 had resection (group A) and 60 had biopsy (group B). Functional outcomes and survival at follow-up were analyzed. RESULTS: Group A differed significantly from group B at baseline in having better WHO performance status, better ASA scores, more right-sided tumors, and no basal ganglia or "butterfly" gliomas. Nevertheless, 56% of group A patients had an ASA score of 3. Median survival was 9.5 months (95% CI 8-17 months) in group A, 4 months (95% CI 3.5-6 months) in group B, and 17.5 months (95% CI 12-24 months) in the 56% of group A patients treated with resection and Stupp protocol. Rates of postoperative neurologic and medical complications were almost identical in the 2 groups, but the rate of surgical site complications was substantially greater in group A (12% vs 5%). There was no significant difference in mean preoperative and postoperative KPS scores (group A). CONCLUSIONS: In selected patients 80 years or older, radical removal of GBM was associated with acceptable survival and a low perioperative complication rate which is comparable to that of a biopsy. Although the median survival of the whole group was lower than reported for younger patients, a subgroup amenable to radical surgery and Stupp protocol achieved a median survival of 17.5 months.
OBJECTIVE: To evaluate the role and possible complications of tumor resection in the management of glioblastoma (GBM) in a series of patients 80 years of age and older with review of literature. METHODS: The authors retrospectively analyzed cases involving patients 80 years or older who underwent biopsy or initial resection of GBM at their hospital between 2007 and 2018. A total of 117 patients (mean age 82 years) met the inclusion criteria; 57 had resection (group A) and 60 had biopsy (group B). Functional outcomes and survival at follow-up were analyzed. RESULTS: Group A differed significantly from group B at baseline in having better WHO performance status, better ASA scores, more right-sided tumors, and no basal ganglia or "butterfly" gliomas. Nevertheless, 56% of group A patients had an ASA score of 3. Median survival was 9.5 months (95% CI 8-17 months) in group A, 4 months (95% CI 3.5-6 months) in group B, and 17.5 months (95% CI 12-24 months) in the 56% of group A patients treated with resection and Stupp protocol. Rates of postoperative neurologic and medical complications were almost identical in the 2 groups, but the rate of surgical site complications was substantially greater in group A (12% vs 5%). There was no significant difference in mean preoperative and postoperative KPS scores (group A). CONCLUSIONS: In selected patients 80 years or older, radical removal of GBM was associated with acceptable survival and a low perioperative complication rate which is comparable to that of a biopsy. Although the median survival of the whole group was lower than reported for younger patients, a subgroup amenable to radical surgery and Stupp protocol achieved a median survival of 17.5 months.
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