Literature DB >> 33659336

NMR waterLOGSY as An Assay in Drug Development Programmes for Detecting Protein-Ligand Interactions-NMR waterLOGSY.

Carole J R Bataille1, Terence H Rabbitts2, Timothy D W Claridge1.   

Abstract

In drug development programmes, multiple assays are needed for the determination of protein-compound interactions and evaluation of potential use in assays with protein-protein interactions. In this protocol we describe the waterLOGSY NMR method for confirming protein-ligand binding events.
Copyright © The Authors; exclusive licensee Bio-protocol LLC.

Entities:  

Keywords:  Drug discovery; Drugs; Ligand binding; NMR; Protein-protein interaction; WaterLOGSY

Year:  2020        PMID： 33659336      PMCID： PMC7842718          DOI： 10.21769/BioProtoc.3666

Source DB:  PubMed          Journal:  Bio Protoc        ISSN： 2331-8325


  4 in total

1.  WaterLOGSY as a method for primary NMR screening: practical aspects and range of applicability.

Authors:  C Dalvit; G Fogliatto; A Stewart; M Veronesi; B Stockman
Journal:  J Biomol NMR       Date:  2001-12       Impact factor: 2.835

2.  Practical aspects of NMR-based fragment screening.

Authors:  Christopher A Lepre
Journal:  Methods Enzymol       Date:  2011       Impact factor: 1.600

Review 3.  Protein-Small Molecule Interactions by WaterLOGSY.

Authors:  Renjie Huang; Ivanhoe K H Leung
Journal:  Methods Enzymol       Date:  2018-09-20       Impact factor: 1.600

4.  Identification of compounds with binding affinity to proteins via magnetization transfer from bulk water.

Authors:  C Dalvit; P Pevarello; M Tatò; M Veronesi; A Vulpetti; M Sundström
Journal:  J Biomol NMR       Date:  2000-09       Impact factor: 2.835
  4 in total
  1 in total

Review 1.  Biophysical Approaches for the Characterization of Protein-Metabolite Interactions.

Authors:  Anja Thalhammer; Nina K Bröker
Journal:  Methods Mol Biol       Date:  2023
  1 in total

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