| Literature DB >> 33659260 |
Daxi Wang1,2, Yanqun Wang3, Wanying Sun1,2,4, Lu Zhang3,5, Jingkai Ji1,2, Zhaoyong Zhang3, Xinyi Cheng1,2,6, Yimin Li3, Fei Xiao7, Airu Zhu3, Bei Zhong8, Shicong Ruan9, Jiandong Li1,2,4, Peidi Ren1,2, Zhihua Ou1,2, Minfeng Xiao1,2, Min Li1,2,4, Ziqing Deng1,2, Huanzi Zhong1,2,10, Fuqiang Li1,2,11, Wen-Jing Wang1,11, Yongwei Zhang1, Weijun Chen4,12, Shida Zhu1,13, Xun Xu1,14, Xin Jin1, Jingxian Zhao3, Nanshan Zhong3, Wenwei Zhang1, Jincun Zhao3,5, Junhua Li1,2,6, Yonghao Xu3.
Abstract
The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions.Entities:
Keywords: SARS-CoV-2; evolution; human to human transmission; intra-host variation; population bottleneck
Year: 2021 PMID： 33659260 PMCID： PMC7917136 DOI： 10.3389/fmed.2021.585358
Source DB: PubMed Journal: Front Med (Lausanne) ISSN： 2296-858X