Literature DB >> 33658548

Synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using HMTA-BAIL@MIL-101(Cr) as a superior heterogeneous catalyst.

Mohammad Hossein Abdollahi-Basir1, Boshra Mirhosseini-Eshkevari2,3, Farzad Zamani4, Mohammad Ali Ghasemzadeh5.   

Abstract

A one-pot three component reaction of benzaldehydes, 1H-tetrazole-5-amine, and 3-cyanoacetyl indole in the presence of a new hexamethylenetetramine-based ionic liquid/MIL-101(Cr) metal-organic framework as a recyclable catalyst was explored. This novel catalyst, which was fully characterized by XRD, FE-SEM, EDX, FT-IR, TGA, BET, and TEM exhibited outstanding catalytic activity for the preparation of a range of pharmaceutically important tetrazolo[1,5-a]pyrimidine-6-carbonitriles with good to excellent yields in short reaction time.

Entities:  

Year:  2021        PMID： 33658548      PMCID： PMC7930133          DOI： 10.1038/s41598-021-84379-3

Source DB:  PubMed          Journal:  Sci Rep        ISSN： 2045-2322            Impact factor:   4.379


  13 in total

Review 1.  An insight into the medicinal perspective of synthetic analogs of indole: A review.

Authors:  Vishali Garg; Rahul Kumar Maurya; Punniyakoti Veeraveedu Thanikachalam; Garima Bansal; Vikramdeep Monga
Journal:  Eur J Med Chem       Date:  2019-07-11       Impact factor: 6.514

Review 2.  Rings in drugs.

Authors:  Richard D Taylor; Malcolm MacCoss; Alastair D G Lawson
Journal:  J Med Chem       Date:  2014-02-17       Impact factor: 7.446

3.  Metal-Organic Frameworks as Catalysts for Organic Synthesis: A Critical Perspective.

Authors:  Vlad Pascanu; Greco González Miera; A Ken Inge; Belén Martín-Matute
Journal:  J Am Chem Soc       Date:  2019-04-23       Impact factor: 15.419

4.  A chromium terephthalate-based solid with unusually large pore volumes and surface area.

Authors:  G Férey; C Mellot-Draznieks; C Serre; F Millange; J Dutour; S Surblé; I Margiolaki
Journal:  Science       Date:  2005-09-23       Impact factor: 47.728

5.  Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice.

Authors:  Ramesh Gujjar; Alka Marwaha; Farah El Mazouni; John White; Karen L White; Sharon Creason; David M Shackleford; Jeffrey Baldwin; William N Charman; Frederick S Buckner; Susan Charman; Pradipsinh K Rathod; Margaret A Phillips
Journal:  J Med Chem       Date:  2009-04-09       Impact factor: 7.446

6.  Synthesis, antifungal activity and CoMFA analysis of novel 1,2,4-triazolo[1,5-a]pyrimidine derivatives.

Authors:  Qiong Chen; Xiao-Lei Zhu; Li-Li Jiang; Zu-Ming Liu; Guang-Fu Yang
Journal:  Eur J Med Chem       Date:  2007-05-27       Impact factor: 6.514

7.  Synthesis and antimicrobical evaluation of a novel class of 1,3,4-thiadiazole: derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety.

Authors:  Yin Luo; Shuai Zhang; Zhi-Jun Liu; Wu Chen; Jie Fu; Qing-Fu Zeng; Hai-Liang Zhu
Journal:  Eur J Med Chem       Date:  2013-04-15       Impact factor: 6.514

8.  Investigation of Ionic Liquid interaction with ZnBDC-Metal Organic Framework through Scanning EXAFS and Inelastic Neutron Scattering.

Authors:  Rituraj Dutta; Mala N Rao; Ashok Kumar
Journal:  Sci Rep       Date:  2019-10-14       Impact factor: 4.379

9.  One-Pot Multicomponent Synthesis and Cytotoxic Evaluation of Novel 7-Substituted-5-(1H-Indol-3-yl)Tetrazolo[1,5-a] Pyrimidine-6-Carbonitrile.

Authors:  Mohamed A A Radwan; Fahad M Alminderej; Hanem M Awad
Journal:  Molecules       Date:  2020-01-08       Impact factor: 4.411

10.  Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase.

Authors:  Alka Marwaha; John White; Farah El Mazouni; Sharon A Creason; Sreekanth Kokkonda; Frederick S Buckner; Susan A Charman; Margaret A Phillips; Pradipsinh K Rathod
Journal:  J Med Chem       Date:  2012-08-21       Impact factor: 7.446
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