Pavel Borsky1, Marcela Chmelarova2, Zdenek Fiala3, Kvetoslava Hamakova4, Vladimir Palicka2, Jan Krejsek5, Ctirad Andrys5, Jan Kremlacek6, Vit Rehacek7, Martin Beranek2, Andrea Malkova3, Tereza Svadlakova3,5, Drahomira Holmannova3, Lenka Borska6. 1. Institute of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, Simkova 870, 50038, Hradec Kralove, Czech Republic. borskyp@lfhk.cuni.cz. 2. Institute of Clinical Biochemistry and Diagnostics, University Hospital Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic. 3. Institute of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, Simkova 870, 50038, Hradec Kralove, Czech Republic. 4. Clinic of Dermatology and Venereology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic. 5. Institute of Clinical Immunology and Allergology, University Hospital and Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic. 6. Institute of Pathological Physiology, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic. 7. Transfusion Center, University Hospital, 500 03, Hradec Kralove, Czech Republic.
Abstract
BACKGROUND: Psoriasis vulgaris is a skin autoimmune disease. Psoriatic patients have significantly lowered life expectancy and suffer from various comorbidities. The main goal of the study was to determine whether psoriatic patients experience accelerated aging. As accelerated aging might be the reason for the higher prevalence of comorbidities at lower chronological ages, we also wanted to investigate the relationship between aging and selected parameters of frequent psoriatic comorbidities - endocan, vascular endothelial growth factor and interleukin-17. Samples were obtained from 28 patients and 42 healthy controls. Epigenetic age measurement was based on the Horvath clock. The levels of endocan, vascular endothelial growth factor and interleukin-17 were analyzed using standardized ELISA methods. RESULTS: The difference between the epigenetic age and the chronological age of each individual subject did not increase with the increasing chronological age of patients. We cannot conclude that psoriasis causes accelerated aging. However, the epigenetic and chronological age difference was significantly higher in female patients than in female controls, and the difference was correlated with endocan (r = 0.867, p = 0.0012) and vascular endothelial growth factor (r = 0.633, p = 0.0365) only in female patients. CONCLUSIONS: The findings suggest a possible presence of pathophysiological processes that occur only in female psoriatic patients. These processes make psoriatic females biologically older and might lead to an increased risk of comorbidity occurrence. This study also supports the idea that autoimmune diseases cause accelerated aging, which should be further explored in the future.
BACKGROUND:Psoriasis vulgaris is a skin autoimmune disease. Psoriaticpatients have significantly lowered life expectancy and suffer from various comorbidities. The main goal of the study was to determine whether psoriaticpatients experience accelerated aging. As accelerated aging might be the reason for the higher prevalence of comorbidities at lower chronological ages, we also wanted to investigate the relationship between aging and selected parameters of frequent psoriatic comorbidities - endocan, vascular endothelial growth factor and interleukin-17. Samples were obtained from 28 patients and 42 healthy controls. Epigenetic age measurement was based on the Horvath clock. The levels of endocan, vascular endothelial growth factor and interleukin-17 were analyzed using standardized ELISA methods. RESULTS: The difference between the epigenetic age and the chronological age of each individual subject did not increase with the increasing chronological age of patients. We cannot conclude that psoriasis causes accelerated aging. However, the epigenetic and chronological age difference was significantly higher in female patients than in female controls, and the difference was correlated with endocan (r = 0.867, p = 0.0012) and vascular endothelial growth factor (r = 0.633, p = 0.0365) only in female patients. CONCLUSIONS: The findings suggest a possible presence of pathophysiological processes that occur only in female psoriaticpatients. These processes make psoriatic females biologically older and might lead to an increased risk of comorbidity occurrence. This study also supports the idea that autoimmune diseases cause accelerated aging, which should be further explored in the future.
Authors: Riccardo E Marioni; Sonia Shah; Allan F McRae; Stuart J Ritchie; Graciela Muniz-Terrera; Sarah E Harris; Jude Gibson; Paul Redmond; Simon R Cox; Alison Pattie; Janie Corley; Adele Taylor; Lee Murphy; John M Starr; Steve Horvath; Peter M Visscher; Naomi R Wray; Ian J Deary Journal: Int J Epidemiol Date: 2015-01-22 Impact factor: 7.196
Authors: Drahomira Holmannova; Pavel Borsky; Lenka Borska; Ctirad Andrys; Kvetoslava Hamakova; Vit Rehacek; Tereza Svadlakova; Andrea Malkova; Martin Beranek; Vladimir Palicka; Jan Krejsek; Zdenek Fiala Journal: Int J Mol Sci Date: 2020-08-05 Impact factor: 5.923