Mary Roberts Davis1, Christopher S Lee2, Amy Corcoran3, Nandita Gupta4, Izabella Uchmanowicz5, Quin E Denfeld6. 1. Oregon Health & Science University School of Nursing, 3455 S.W. U.S. Veterans Hospital Road, Portland, OR 97239-2941, USA. Electronic address: davmar@ohsu.edu. 2. Boston College William F. Connell School of Nursing, 140 Commonwealth Avenue, Boston, MA 02467, USA. Electronic address: christopher.lee.8@bc.edu. 3. Oregon Health & Science University, Knight Cardiovascular Institute, 808 S.W. Campus Drive, Portland, OR 97239, USA. Electronic address: corcoraa@ohsu.edu. 4. Oregon Health & Science University, Knight Cardiovascular Institute, 808 S.W. Campus Drive, Portland, OR 97239, USA. Electronic address: gupta@ohsu.edu. 5. Department of Clinical Nursing, Wrocław Medical University, K. Bartla 5, 51-618 Wroclaw, Poland. Electronic address: izabella.uchmanowicz@eckp.wroclaw.pl. 6. Oregon Health & Science University School of Nursing, 3455 S.W. U.S. Veterans Hospital Road, Portland, OR 97239-2941, USA. Electronic address: denfeldq@ohsu.edu.
Abstract
OBJECTIVES: This study quantitatively synthesized literature to identify gender differences in the prevalence of frailty in heart failure (HF). BACKGROUND: The intersection of frailty and HF continues to garner interest. Almost half of patients with HF are frail; however, gender differences in frailty in HF are poorly understood. METHODS: We performed a literature search to identify studies that reported prevalence of frailty by gender in HF. Random-effects meta-analysis was used to quantify the relative and absolute risk of frailty in women compared with men with HF, overall, and by Physical and Multidimensional Frailty measures. Meta-regression was performed to examine the influence of study age and functional class on relative risk in HF. RESULTS: Twenty-nine studies involving 8854 adults with HF were included. Overall in HF, women had a 26% higher relative risk of being frail compared with men (95% CI = 1.14-1.38, z = 4.69, p < 0.001, I2 = 76.5%). The overall absolute risk for women compared to men with HF being frail was 10% (95% CI = 0.06-0.15, z = 4.41, p < 0.001). The relative risk of frailty was slightly higher among studies that used Physical measures (relative risk = 1.27, p < 0.001) compared with studies that used Multidimensional measures (relative risk = 1.24, p = 0.024). There were no significant relationships between relative risk and either study age or functional class. CONCLUSIONS: In HF, frailty affects women significantly more than men. Future work should focus on elucidating potential causes of gender differences in frailty in HF.
OBJECTIVES: This study quantitatively synthesized literature to identify gender differences in the prevalence of frailty in heart failure (HF). BACKGROUND: The intersection of frailty and HF continues to garner interest. Almost half of patients with HF are frail; however, gender differences in frailty in HF are poorly understood. METHODS: We performed a literature search to identify studies that reported prevalence of frailty by gender in HF. Random-effects meta-analysis was used to quantify the relative and absolute risk of frailty in women compared with men with HF, overall, and by Physical and Multidimensional Frailty measures. Meta-regression was performed to examine the influence of study age and functional class on relative risk in HF. RESULTS: Twenty-nine studies involving 8854 adults with HF were included. Overall in HF, women had a 26% higher relative risk of being frail compared with men (95% CI = 1.14-1.38, z = 4.69, p < 0.001, I2 = 76.5%). The overall absolute risk for women compared to men with HF being frail was 10% (95% CI = 0.06-0.15, z = 4.41, p < 0.001). The relative risk of frailty was slightly higher among studies that used Physical measures (relative risk = 1.27, p < 0.001) compared with studies that used Multidimensional measures (relative risk = 1.24, p = 0.024). There were no significant relationships between relative risk and either study age or functional class. CONCLUSIONS: In HF, frailty affects women significantly more than men. Future work should focus on elucidating potential causes of gender differences in frailty in HF.
Authors: Linda P Fried; Luigi Ferrucci; Jonathan Darer; Jeff D Williamson; Gerard Anderson Journal: J Gerontol A Biol Sci Med Sci Date: 2004-03 Impact factor: 6.053
Authors: Quin E Denfeld; Kerri Winters-Stone; James O Mudd; Jill M Gelow; Sawsan Kurdi; Christopher S Lee Journal: Int J Cardiol Date: 2017-02-10 Impact factor: 4.164
Authors: F Cacciatore; P Abete; F Mazzella; L Viati; D Della Morte; D D'Ambrosio; G Gargiulo; G Testa; D Santis; G Galizia; N Ferrara; F Rengo Journal: Eur J Clin Invest Date: 2005-12 Impact factor: 4.686
Authors: Quin E Denfeld; Beth A Habecker; S Albert Camacho; Mary Roberts Davis; Nandita Gupta; Shirin O Hiatt; Mary E Medysky; Jonathan Q Purnell; Kerri Winters-Stone; Christopher S Lee Journal: Circ Heart Fail Date: 2021-08-25 Impact factor: 10.447
Authors: Imo A Ebong; Ersilia M DeFilippis; Eman A Hamad; Eileen M Hsich; Varinder K Randhawa; Filio Billia; Mahwash Kassi; Anju Bhardwaj; Mirnela Byku; Mrudala R Munagala; Roopa A Rao; Amy E Hackmann; Claudia G Gidea; Teresa DeMarco; Shelley A Hall Journal: Front Cardiovasc Med Date: 2022-07-11
Authors: Chia-Hui Wang; Wen-Pei Chang; Su-Ru Chen; Wan-Ju Cheng; Kuei-Ru Chou; Li-Chung Pien Journal: Int J Environ Res Public Health Date: 2022-07-17 Impact factor: 4.614
Authors: Pablo Díez-Villanueva; César Jiménez-Méndez; Clara Bonanad; Carolina Ortiz-Cortés; Eduardo Barge-Caballero; Josebe Goirigolzarri; Alberto Esteban-Fernández; Angel Pérez-Rivera; Marta Cobo; Ancor Sanz-García; Francesc Formiga; Albert Ariza-Solé; Manuel Martínez-Sellés; Fernando Alfonso Journal: Front Cardiovasc Med Date: 2022-09-12