| Literature DB >> 33656740 |
Ding Luo1, Qing Tang1, Ding-Chai Lin1, Wen-Zhi Wang1, Can-Jie Li1, Xue-Fang Zhuo1, Zhong-Nan Wu1, Yu-Bo Zhang1,2, Guo-Cai Wang3, Yao-Lan Li4.
Abstract
Five matrine-type alkaloids (1‒5) including two new compounds (1 and 3) and a new natural product (2) were isolated from the roots of Sophora tonkinesis. Their structures were identified by extensive spectroscopic analysis (UV, IR, HRESIMS and NMR). The absolute configurations of 2 and 3 were determined by X-ray diffraction. Compounds 1‒5 were evaluated their activity against inflammatory cytokines TNF-α and IL-6 levels on LPS-induced RAW 264.7 macrophages, and compound 1 showed the most significant activity, potent than that of matrine, the representative ingredient from Sophora plants.Entities:
Keywords: 12,13-dehydrosophoridine; 13β-hydroxymatrine; Anti-inflammatory activity; Matrine-type alkaloid; Sophora tonkinensis
Year: 2021 PMID： 33656740 DOI： 10.1007/s11418-021-01498-x
Source DB: PubMed Journal: J Nat Med ISSN： 1340-3443 Impact factor: 2.343