| Literature DB >> 33656718 |
Fataneh Tavasolian1, Gholam Reza Hatam2, Sayed Hussain Mosawi3, Mahdiyar Iravani Saadi4, Elham Abdollahi5, Tannaz Jamialahmadi6,7,8, Thozhukat Sathyapalan9, Amirhossein Sahebkar10,11,12,13.
Abstract
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly pathogenic with relatively high mortality and morbidity. In addition to pneumonia, acute respiratory distress syndrome, and microembolic disorder, a high proportion of patients with SARS-CoV-2 develop lymphopenia and cytokine storm disorder. This review explores the underlying mechanisms behind the pathogenesis of SARS-CoV-2, especially the immune mechanisms, which could be potentially used as therapeutic targets for the management of COVID-19.Entities:
Keywords: COVID-19; Cytokine storm syndrome; Immune response; Lymphopenia
Year: 2021 PMID： 33656718 DOI： 10.1007/978-3-030-59261-5_10
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622