M A DiIorio1,2, P S Sobiesczcyk1,3, C Xu4, W Huang4, J A Ford1,4, S S Zhao5, D H Solomon1,4, W P Docken1,4, S K Tedeschi1,4. 1. Harvard Medical Faculty, Harvard Medical School, Boston, MA, USA. 2. Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. 3. Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA. 4. Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Boston, MA, USA. 5. Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Abstract
Objectives: Giant cell arteritis (GCA) can manifest in cranial and/or extracranial arteries. We investigated the distribution of affected arteries on vascular ultrasound (VUS) among patients with new-onset or prior-onset GCA.Method: We retrospectively studied patients with either new-onset or prior-onset GCA and an abnormal VUS, from 2013 to 2017. Trained vascular technologists imaged the bilateral temporal arteries and carotid, axillary, and subclavian arteries. Vascular medicine physicians interpreted the images. Vasculitis-related abnormalities in individual vessels and their distribution (temporal artery, large artery, or both) were evaluated. Phi coefficients (φ) and Fisher's exact test were used to assess correlations among individual abnormal arteries. Results: Among 66 GCA patients, 28.8% had prior-onset GCA (median duration 17.8 months). Acute arteritis on VUS was observed in the majority of patients with both new-onset (72.3%) and prior-onset GCA (68.4%); the remainder had hyperechoic wall thickening without acute arteritis. Involvement of the temporal arteries only (45.5%) or large arteries only (34.8%) was more common than involvement of both (19.7%); this finding was similar in new-onset and prior-onset GCA. There were moderate positive correlations among temporal artery branches (φ = 0.51-0.58, p < 0.003) and among axillary and subclavian arteries (φ = 0.51-0.77, p < 0.003), and moderate negative correlations between abnormalities in the temporal and large arteries (φ = -0.46 to -0.58, p < 0.003). Conclusion: On VUS, vasculitis-related abnormalities in the temporal arteries only or large arteries only were more common than concurrent temporal and large artery abnormalities in patients with both new-onset GCA and prior-onset GCA.
Objectives: Giant cell arteritis (GCA) can manifest in cranial and/or extracranial arteries. We investigated the distribution of affected arteries on vascular ultrasound (VUS) among patients with new-onset or prior-onset GCA.Method: We retrospectively studied patients with either new-onset or prior-onset GCA and an abnormal VUS, from 2013 to 2017. Trained vascular technologists imaged the bilateral temporal arteries and carotid, axillary, and subclavian arteries. Vascular medicine physicians interpreted the images. Vasculitis-related abnormalities in individual vessels and their distribution (temporal artery, large artery, or both) were evaluated. Phi coefficients (φ) and Fisher's exact test were used to assess correlations among individual abnormal arteries. Results: Among 66 GCA patients, 28.8% had prior-onset GCA (median duration 17.8 months). Acute arteritis on VUS was observed in the majority of patients with both new-onset (72.3%) and prior-onset GCA (68.4%); the remainder had hyperechoic wall thickening without acute arteritis. Involvement of the temporal arteries only (45.5%) or large arteries only (34.8%) was more common than involvement of both (19.7%); this finding was similar in new-onset and prior-onset GCA. There were moderate positive correlations among temporal artery branches (φ = 0.51-0.58, p < 0.003) and among axillary and subclavian arteries (φ = 0.51-0.77, p < 0.003), and moderate negative correlations between abnormalities in the temporal and large arteries (φ = -0.46 to -0.58, p < 0.003). Conclusion: On VUS, vasculitis-related abnormalities in the temporal arteries only or large arteries only were more common than concurrent temporal and large artery abnormalities in patients with both new-onset GCA and prior-onset GCA.
Authors: Julia A Ford; Michael A DiIorio; Weixing Huang; Piotr Sobiesczcyk; William P Docken; Sara K Tedeschi Journal: Clin Exp Rheumatol Date: 2020-04-27 Impact factor: 4.473
Authors: Anthony M Sammel; Edward Hsiao; Geoffrey Schembri; Katherine Nguyen; Janice Brewer; Leslie Schrieber; Beatrice Janssen; Peter Youssef; Clare L Fraser; Elizabeth Bailey; Dale L Bailey; Paul Roach; Rodger Laurent Journal: Arthritis Rheumatol Date: 2019-06-12 Impact factor: 10.995
Authors: Sergio Prieto-González; Pedro Arguis; Ana García-Martínez; Georgina Espígol-Frigolé; Itziar Tavera-Bahillo; Montserrat Butjosa; Marcelo Sánchez; José Hernández-Rodríguez; Josep M Grau; Maria C Cid Journal: Ann Rheum Dis Date: 2012-01-20 Impact factor: 19.103
Authors: Michael Czihal; Anne Piller; Angelika Schroettle; Peter Kuhlencordt; Christoph Bernau; Hendrik Schulze-Koops; Ulrich Hoffmann Journal: J Vasc Surg Date: 2015-02-03 Impact factor: 4.268
Authors: Reva C Lawrence; David T Felson; Charles G Helmick; Lesley M Arnold; Hyon Choi; Richard A Deyo; Sherine Gabriel; Rosemarie Hirsch; Marc C Hochberg; Gene G Hunder; Joanne M Jordan; Jeffrey N Katz; Hilal Maradit Kremers; Frederick Wolfe Journal: Arthritis Rheum Date: 2008-01
Authors: K Bates Gribbons; Cristina Ponte; Simon Carette; Anthea Craven; David Cuthbertson; Gary S Hoffman; Nader A Khalidi; Curry L Koening; Carol A Langford; Kathleen Maksimowicz-McKinnon; Carol A McAlear; Paul A Monach; Larry W Moreland; Christian Pagnoux; Kaitlin A Quinn; Joanna C Robson; Philip Seo; Antoine G Sreih; Ravi Suppiah; Kenneth J Warrington; Steven R Ytterberg; Raashid Luqmani; Richard Watts; Peter A Merkel; Peter C Grayson Journal: Arthritis Care Res (Hoboken) Date: 2020-11 Impact factor: 5.178