| Literature DB >> 33655273 |
J A Kosmicki, J E Horowitz, N Banerjee, R Lanche, A Marcketta, E Maxwell, X Bai, D Sun, J D Backman, D Sharma, H M Kang, C O'Dushlaine, A Yadav, A J Mansfield, A H Li, K Watanabe, L Gurski, S E McCarthy, A E Locke, S Khalid, S O'Keeffe, J Mbatchou, O Chazara, Y Huang, E Kvikstad, A O'Neill, P Nioi, M M Parker, S Petrovski, H Runz, J D Szustakowski, Q Wang, E Wong, A Cordova-Palomera, E N Smith, S Szalma, X Zheng, S Esmaeeli, J W Davis, Y-P Lai, X Chen, A E Justice, J B Leader, T Mirshahi, D J Carey, A Verma, G Sirugo, M D Ritchie, D J Rader, G Povysil, D B Goldstein, K Kiryluk, E Pairo-Castineira, K Rawlik, D Pasko, S Walker, A Meynert, A Kousathanas, L Moutsianas, A Tenesa, M Caulfield, R Scott, J F Wilson, J K Baillie, G Butler-Laporte, T Nakanishi, M Lathrop, J B Richards, M Jones, S Balasubramanian, W Salerno, A R Shuldiner, J Marchini, J D Overton, L Habegger, M N Cantor, J G Reid, A Baras, G R Abecasis, M A Ferreira.
Abstract
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease-19 (COVID-19), a respiratory illness that can result in hospitalization or death. We investigated associations between rare genetic variants and seven COVID-19 outcomes in 543,213 individuals, including 8,248 with COVID-19. After accounting for multiple testing, we did not identify any clear associations with rare variants either exome-wide or when specifically focusing on (i) 14 interferon pathway genes in which rare deleterious variants have been reported in severe COVID-19 patients; (ii) 167 genes located in COVID-19 GWAS risk loci; or (iii) 32 additional genes of immunologic relevance and/or therapeutic potential. Our analyses indicate there are no significant associations with rare protein-coding variants with detectable effect sizes at our current sample sizes. Analyses will be updated as additional data become available, with results publicly browsable at https://rgc-covid19.regeneron.com .Entities:
Year: 2021 PMID： 33655273 PMCID： PMC7924298 DOI： 10.1101/2020.10.28.20221804
Source DB: PubMed Journal: medRxiv