Literature DB >> 33655250

Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016.

Tyler N Starr1, Allison J Greaney1,2,3, Adam S Dingens1, Jesse D Bloom1,2,4.   

Abstract

Monoclonal antibodies and antibody cocktails are a promising therapeutic and prophylaxis for COVID-19. However, ongoing evolution of SARS-CoV-2 can render monoclonal antibodies ineffective. Here we completely map all mutations to the SARS-CoV-2 spike receptor binding domain (RBD) that escape binding by a leading monoclonal antibody, LY-CoV555, and its cocktail combination with LY-CoV016. Individual mutations that escape binding by each antibody are combined in the circulating B.1.351 and P.1 SARS-CoV-2 lineages (E484K escapes LY-CoV555, K417N/T escape LY-CoV016). Additionally, the L452R mutation in the B.1.429 lineage escapes LY-CoV555. Furthermore, we identify single amino acid changes that escape the combined LY-CoV555+LY-CoV016 cocktail. We suggest that future efforts should diversify the epitopes targeted by antibodies and antibody cocktails to make them more resilient to antigenic evolution of SARS-CoV-2.

Entities:  

Year:  2021        PMID： 33655250      PMCID： PMC7924270          DOI： 10.1101/2021.02.17.431683

Source DB:  PubMed          Journal:  bioRxiv


  24 in total

1.  Emergence of a Novel SARS-CoV-2 Variant in Southern California.

Authors:  Wenjuan Zhang; Brian D Davis; Stephanie S Chen; Jorge M Sincuir Martinez; Jasmine T Plummer; Eric Vail
Journal:  JAMA       Date:  2021-04-06       Impact factor: 56.272

2.  A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2.

Authors:  Rui Shi; Chao Shan; Xiaomin Duan; Zhihai Chen; Peipei Liu; Jinwen Song; Tao Song; Xiaoshan Bi; Chao Han; Lianao Wu; Ge Gao; Xue Hu; Yanan Zhang; Zhou Tong; Weijin Huang; William Jun Liu; Guizhen Wu; Bo Zhang; Lan Wang; Jianxun Qi; Hui Feng; Fu-Sheng Wang; Qihui Wang; George Fu Gao; Zhiming Yuan; Jinghua Yan
Journal:  Nature       Date:  2020-05-26       Impact factor: 49.962

3.  MAFFT multiple sequence alignment software version 7: improvements in performance and usability.

Authors:  Kazutaka Katoh; Daron M Standley
Journal:  Mol Biol Evol       Date:  2013-01-16       Impact factor: 16.240

4.  Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229e.

Authors:  Kathryn E Kistler; Trevor Bedford
Journal:  Elife       Date:  2021-01-19       Impact factor: 8.713

5.  Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization.

Authors:  Zhuoming Liu; Laura A VanBlargan; Louis-Marie Bloyet; Paul W Rothlauf; Rita E Chen; Spencer Stumpf; Haiyan Zhao; John M Errico; Elitza S Theel; Mariel J Liebeskind; Brynn Alford; William J Buchser; Ali H Ellebedy; Daved H Fremont; Michael S Diamond; Sean P J Whelan
Journal:  Cell Host Microbe       Date:  2021-01-27       Impact factor: 31.316

6.  Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model.

Authors:  Thomas F Rogers; Fangzhu Zhao; Deli Huang; Nathan Beutler; Alison Burns; Wan-Ting He; Oliver Limbo; Chloe Smith; Ge Song; Jordan Woehl; Linlin Yang; Robert K Abbott; Sean Callaghan; Elijah Garcia; Jonathan Hurtado; Mara Parren; Linghang Peng; Sydney Ramirez; James Ricketts; Michael J Ricciardi; Stephen A Rawlings; Nicholas C Wu; Meng Yuan; Davey M Smith; David Nemazee; John R Teijaro; James E Voss; Ian A Wilson; Raiees Andrabi; Bryan Briney; Elise Landais; Devin Sok; Joseph G Jardine; Dennis R Burton
Journal:  Science       Date:  2020-06-15       Impact factor: 47.728

7.  A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies.

Authors:  Ahmed O Hassan; James Brett Case; Emma S Winkler; Larissa B Thackray; Natasha M Kafai; Adam L Bailey; Broc T McCune; Julie M Fox; Rita E Chen; Wafaa B Alsoussi; Jackson S Turner; Aaron J Schmitz; Tingting Lei; Swathi Shrihari; Shamus P Keeler; Daved H Fremont; Suellen Greco; Paul B McCray; Stanley Perlman; Michael J Holtzman; Ali H Ellebedy; Michael S Diamond
Journal:  Cell       Date:  2020-06-10       Impact factor: 66.850

8.  SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19.

Authors:  Peter Chen; Ajay Nirula; Barry Heller; Robert L Gottlieb; Joseph Boscia; Jason Morris; Gregory Huhn; Jose Cardona; Bharat Mocherla; Valentina Stosor; Imad Shawa; Andrew C Adams; Jacob Van Naarden; Kenneth L Custer; Lei Shen; Michael Durante; Gerard Oakley; Andrew E Schade; Janelle Sabo; Dipak R Patel; Paul Klekotka; Daniel M Skovronsky
Journal:  N Engl J Med       Date:  2020-10-28       Impact factor: 91.245

9.  Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms.

Authors:  M Alejandra Tortorici; Martina Beltramello; Florian A Lempp; Dora Pinto; Ha V Dang; Laura E Rosen; Matthew McCallum; John Bowen; Andrea Minola; Stefano Jaconi; Fabrizia Zatta; Anna De Marco; Barbara Guarino; Siro Bianchi; Elvin J Lauron; Heather Tucker; Jiayi Zhou; Alessia Peter; Colin Havenar-Daughton; Jason A Wojcechowskyj; James Brett Case; Rita E Chen; Hannah Kaiser; Martin Montiel-Ruiz; Marcel Meury; Nadine Czudnochowski; Roberto Spreafico; Josh Dillen; Cindy Ng; Nicole Sprugasci; Katja Culap; Fabio Benigni; Rana Abdelnabi; Shi-Yan Caroline Foo; Michael A Schmid; Elisabetta Cameroni; Agostino Riva; Arianna Gabrieli; Massimo Galli; Matteo S Pizzuto; Johan Neyts; Michael S Diamond; Herbert W Virgin; Gyorgy Snell; Davide Corti; Katja Fink; David Veesler
Journal:  Science       Date:  2020-09-24       Impact factor: 47.728
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  2 in total

1.  Evolution of antibody immunity following Omicron BA.1 breakthrough infection.

Authors:  Chengzi I Kaku; Tyler N Starr; Panpan Zhou; Haley L Dugan; Paul Khalifé; Ge Song; Elizabeth R Champney; Daniel W Mielcarz; James C Geoghegan; Dennis R Burton; Raiees Andrabi; Jesse D Bloom; Laura M Walker
Journal:  bioRxiv       Date:  2022-09-22

Review 2.  Recent highlights on Omicron as a new SARS-COVID-19 variant: evolution, genetic mutation, and future perspectives.

Authors:  Pooja Khairnar; Mukesh Soni; Mayank Handa; Yassine Riadi; Prashant Kesharwani; Rahul Shukla
Journal:  J Drug Target       Date:  2022-03-28       Impact factor: 5.016
  2 in total

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