Continuous flow fast atom bombardment liquid chromatography/mass spectrometry: studies involving conventional bore liquid chromatography with simultaneous ultraviolet detection.

A conventional bore liquid chromatograph has been interfaced to quadrupole and magnetic sector mass spectrometers configured for fast atom bombardment ionization via a continuous flow FAB probe. It is shown that post-column addition of FAB matrix and in-line ultraviolet detection facilities do not significantly compromise chromatographic integrity and that high quality mass spectra are obtainable from such FAB LC/MS studies.