Literature DB >> 33654842

Cylinder Test to Assess Sensory-motor Function in a Mouse Model of Parkinson's Disease.

Luiz Alexandre Viana Magno1, Mélcar Collodetti1, Helia Tenza-Ferrer1, Marco Aurélio Romano-Silva1,2.   

Abstract

Parkinson's disease is a progressive neurodegenerative movement disorder that happens due to the loss of dopaminergic neurons in the substantia nigra. The deficiency of dopamine in the basal nuclei drives cardinal motor symptoms such as bradykinesia and hypokinesia. The current protocol describes the cylinder test, which is a relatively simple behavioral assessment that evaluates the motor deficits upon unilateral degeneration of the nigrostriatal pathway in experimental models of Parkinson's disease. Since dopamine-depleted mice exhibit the preferential use of the forelimb ipsilateral to the lesion, here researchers perform the cylinder test to investigate the therapeutic effects of antiparkinsonian treatments on the performance of the contralateral (injured) limb.
Copyright © 2019 The Authors; exclusive licensee Bio-protocol LLC.

Entities:  

Keywords:  Behavior; Cylinder test; Motor system; Parkinson’s disease; Stroke

Year:  2019        PMID： 33654842      PMCID： PMC7854261          DOI： 10.21769/BioProtoc.3337

Source DB:  PubMed          Journal:  Bio Protoc        ISSN： 2331-8325


  15 in total

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7.  Optogenetic Stimulation of the M2 Cortex Reverts Motor Dysfunction in a Mouse Model of Parkinson's Disease.

Authors:  Luiz Alexandre Viana Magno; Helia Tenza-Ferrer; Mélcar Collodetti; Matheus Felipe Guimarães Aguiar; Ana Paula Carneiro Rodrigues; Rodrigo Souza da Silva; Joice do Prado Silva; Nycolle Ferreira Nicolau; Daniela Valadão Freitas Rosa; Alexander Birbrair; Débora Marques Miranda; Marco Aurélio Romano-Silva
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Authors:  V R Venna; Y Xu; S J Doran; A Patrizz; L D McCullough
Journal:  Transl Psychiatry       Date:  2014-01-28       Impact factor: 6.222
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  3 in total

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