Min-Hua Lin1,2, She-Yu Chiu3, Wen-Chao Ho4,5, Kai-Hsien Chi6, Tsung-Yun Liu6, I-Jen Wang7,8,9,10,11. 1. Department of Nutrition, China Medical University, No.100, Sec.1, Jingmao Road, Beitun Dist, Taichung, 4046040, Taiwan. 2. Department of Dietetics, Yunlin Christian Hospital, No.375, Shichang S Road, Xiluo Township, Yunlin, 648102, Taiwan. 3. Institute of Population Health Sciences, National Health Research Institutes, No.35, Keyan Road, Zhunan Township, Miaoli, 35053, Taiwan. 4. College of Public Health, China Medical University, No.100, Sec.1, Jingmao Road, Beitun Dist, Taichung, 406040, Taiwan. 5. Department of Nursing & Graduate Institute of Nursing, Asia University, No.500, Lioufeng Road, Wufeng, Taichung, 41354, Taiwan. 6. School of Medicine, National Yang Ming Chiao Tung University, No.155, Sec.2, Linong Street, Taipei, 11221, Taiwan. 7. College of Public Health, China Medical University, No.100, Sec.1, Jingmao Road, Beitun Dist, Taichung, 406040, Taiwan. wij636@gmail.com. 8. School of Medicine, National Yang Ming Chiao Tung University, No.155, Sec.2, Linong Street, Taipei, 11221, Taiwan. wij636@gmail.com. 9. Department of Pediatrics, Taipei Hospital, Ministry of Health and Welfare, New Taipei City, 24213, Taiwan. wij636@gmail.com. 10. National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, 350401, Taiwan. wij636@gmail.com. 11. National Taiwan University, Taipei, 10617, Taiwan. wij636@gmail.com.
Abstract
BACKGROUND: Few studies have assessed associations between allergic diseases and antibacterial agents in Taiwanese children. OBJECTIVE: This study aimed to investigate the association of triclosan (TCS) exposure with allergic diseases among preschoolers, disease-specific IgE titers, and a child's sex. METHODS: Pediatric data were obtained from the Childhood Environment and Allergic Diseases Study (CEAS; 2010) cohort, and their urine and blood samples were used to analyze TCS and IgE concentrations (age 3 group). Three years later, clinical data were obtained again from the age 3 group (age 6 group). Correlations of TCS levels at ages 3 and 6 years with IgE levels and allergic diseases were evaluated. RESULTS: The TCS levels were higher at age 3 than at age 6 (geometric mean, 1.05 ng/ml vs 0.37 ng/ml). TCS levels were positively correlated with serum IgE levels at ages 3 and 6 years. Asthma and atopic dermatitis were significantly associated with TCS (adjusted OR 1.14, 95% confidence interval [CI] 1.01-1.29; OR 1.22, 95% CI 1.05-1.41). Sex-stratified analysis revealed that TCS levels were positively correlated with IgE levels among boys in the age 6 group and significantly associated with asthma, allergic rhinitis, and atopic dermatitis among boys. SIGNIFICANCE: TCS exposure is associated with IgE levels and a potentially high risk of pediatric atopic disorders.
BACKGROUND: Few studies have assessed associations between allergic diseases and antibacterial agents in Taiwanese children. OBJECTIVE: This study aimed to investigate the association of triclosan (TCS) exposure with allergic diseases among preschoolers, disease-specific IgE titers, and a child's sex. METHODS: Pediatric data were obtained from the Childhood Environment and Allergic Diseases Study (CEAS; 2010) cohort, and their urine and blood samples were used to analyze TCS and IgE concentrations (age 3 group). Three years later, clinical data were obtained again from the age 3 group (age 6 group). Correlations of TCS levels at ages 3 and 6 years with IgE levels and allergic diseases were evaluated. RESULTS: The TCS levels were higher at age 3 than at age 6 (geometric mean, 1.05 ng/ml vs 0.37 ng/ml). TCS levels were positively correlated with serum IgE levels at ages 3 and 6 years. Asthma and atopic dermatitis were significantly associated with TCS (adjusted OR 1.14, 95% confidence interval [CI] 1.01-1.29; OR 1.22, 95% CI 1.05-1.41). Sex-stratified analysis revealed that TCS levels were positively correlated with IgE levels among boys in the age 6 group and significantly associated with asthma, allergic rhinitis, and atopic dermatitis among boys. SIGNIFICANCE: TCS exposure is associated with IgE levels and a potentially high risk of pediatric atopic disorders.