| Literature DB >> 33654250 |
Kazunari Sakai1, Masato Iwatsuki2,3, Masato Iizuka4, Yukihiro Asami1,4, Kenichi Nonaka1,4, Rokuro Masuma1,4, Mami Takizawa4, Takuji Nakashima1, Toshiyuki Tokiwa1, Kazuro Shiomi1,4, Satoshi Ōmura1.
Abstract
An anti-mannheimiosis agent, aldsulfin, was isolated from a culture broth of the fungus Lasiodiplodia pseudotheobromae FKI-4499, together with a known compound, lasiodipline C, using bioassay-guided fractionation. Spectroscopic analysis of aldsulfin, using NMR, mass spectrometry, and CD analyses revealed it to be an epithiodiketopiperazine with an unstable and unusual hemithioaminal moiety. Aldsulfin showed antibacterial activity against Mannheimia haemolytica and Pasteurella multocida.Entities:
Year: 2021 PMID： 33654250 DOI： 10.1038/s41429-021-00411-8
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649