| Literature DB >> 33654063 |
Le Chang1,2, Wangheng Hou3,4, Lei Zhao5,6, Yali Zhang3,4, Yanbin Wang7, Linfeng Wu8, Tingting Xu5,6, Lilin Wang8, Juan Wang3,4, Jian Ma3,4, Lan Wang9, Junpeng Zhao8, Jing Xu9, Juan Dong5,6, Ying Yan1,2, Ru Yang10, Yu Li5,6, Fei Guo1,2, Wenjuan Cheng5,6, Yingying Su3,4, Jinfeng Zeng8, Wei Han7, Tong Cheng3,4, Jun Zhang3,4, Quan Yuan11,12, Ningshao Xia3,4, Lunan Wang13,14,15.
Abstract
In this study, we investigate the seroprevalence of SARS-CoV-2 antibodies among blood donors in the cities of Wuhan, Shenzhen, and Shijiazhuang in China. From January to April 2020, 38,144 healthy blood donors in the three cities were tested for total antibody against SARS-CoV-2 followed by pseudotype SARS-CoV-2 neutralization tests, IgG, and IgM antibody testing. Finally, a total of 398 donors were confirmed positive. The age- and sex-standardized SARS-CoV-2 seroprevalence among 18-60 year-old adults (18-65 year-old in Shenzhen) was 2.66% (95% CI: 2.24%-3.07%) in Wuhan, 0.033% (95% CI: 0.0029%-0.267%) in Shenzhen, and 0.0028% (95% CI: 0.0001%-0.158%) in Shijiazhuang, respectively. Female sex and older-age were identified to be independent risk factors for SARS-CoV-2 seropositivity among blood donors in Wuhan. As most of the population of China remained uninfected during the early wave of the COVID-19 pandemic, effective public health measures are still certainly required to block viral spread before a vaccine is widely available.Entities:
Year: 2021 PMID： 33654063 DOI： 10.1038/s41467-021-21503-x
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919