Literature DB >> 33654014

COVID-19 new diagnostics development: novel detection methods for SARS-CoV-2 infection and considerations for their translation to routine use.

Jim F Huggett1,2, Jacob Moran-Gilad3, J Eugene Lee4.   

Abstract

PURPOSE OF REVIEW: COVID-19 has put the in-vitro-diagnostic community under an unprecedented spotlight, with a global requirement for accurate SARS-CoV-2 tests. This review will outline technological responses to this need and the analytical considerations required for their translation to routine use. RECENT
FINDINGS: SARS-CoV-2 diagnostic solutions directly detect the virus or measure host-derived surrogate markers of infection. With pressure upon supply chains for the 'traditional' molecular approaches, a wide variety of analytical tools spanning the molecular, serology, imaging and chemistry space are being developed, including high throughput solutions and simplified near-patient formats.
SUMMARY: The unique genetic nature of SARS-CoV-2 means high analytical specificity is achievable by most diagnostic formats. However, clinical sensitivity assessment is complicated by wide discrepancies in analytical range and challenges associated with standardising these differences. When coupled with the acute nature of SARS-CoV-2 infection, reported precise metrics of test performance must be questioned. The response to SARS-CoV-2 has delivered considerable diagnostic innovation, but for a technology to be maximised, it must be demonstrably reproducible and fit for purpose. If novel diagnostic solutions for SARS-CoV-2 are to succeed, equally innovative mechanisms are needed to ensure widespread clinical and surveillance application, enabling agreed standards and metrics to ensure comparability.
Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.

Entities:  

Mesh:

Year:  2021        PMID: 33654014     DOI: 10.1097/MCP.0000000000000768

Source DB:  PubMed          Journal:  Curr Opin Pulm Med        ISSN: 1070-5287            Impact factor:   3.155


  5 in total

1.  Plasmonic Fiberoptic Absorbance Biosensor (P-FAB) for Rapid Detection of SARS-CoV-2 Nucleocapsid Protein.

Authors:  M Divagar; R Gayathri; Rahiel Rasool; J Kuzhandai Shamlee; Himanshu Bhatia; Jitendra Satija; V V R Sai
Journal:  IEEE Sens J       Date:  2021-08-24       Impact factor: 3.301

Review 2.  Advanced Molecular and Immunological Diagnostic Methods to Detect SARS-CoV-2 Infection.

Authors:  John Charles Rotondo; Fernanda Martini; Martina Maritati; Elisabetta Caselli; Carla Enrica Gallenga; Matteo Guarino; Roberto De Giorgio; Chiara Mazziotta; Maria Letizia Tramarin; Giada Badiale; Mauro Tognon; Carlo Contini
Journal:  Microorganisms       Date:  2022-06-10

Review 3.  Performance Evaluation of Lateral Flow Assays for Coronavirus Disease-19 Serology.

Authors:  Lucy Ochola; Paul Ogongo; Samuel Mungai; Jesse Gitaka; Sara Suliman
Journal:  Clin Lab Med       Date:  2021-11-03       Impact factor: 1.935

4.  Measuring diagnostic performance of COVID-19 tests: lessons for the next pandemic.

Authors:  Jacob Moran-Gilad
Journal:  Euro Surveill       Date:  2021-11

5.  A SARS-Cov-2 sensor based on upconversion nanoparticles and graphene oxide.

Authors:  Konstantina Alexaki; Maria Eleni Kyriazi; Joshua Greening; Lapatrada Taemaitree; Afaf H El-Sagheer; Tom Brown; Xunli Zhang; Otto L Muskens; Antonios G Kanaras
Journal:  RSC Adv       Date:  2022-06-22       Impact factor: 4.036

  5 in total

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