Upregulation of circ_PVT1 and circ_001569 Indicate Unfavorable Prognosis in Colorectal Cancer.

Colorectal cancer is one of the most frequent cancers with over 1.3 million new cases annually. CircularRNAs (circRNAs) are involved in different cancer cells' malignancy regulation. Nevertheless, the clinical values of circRNAs in colorectal cancer (CRC) remains unclear. In this study, we investigated circ_PVT1 and circ_001569 expressions in the CRC and healthy controls' plasma. Furthermore, we used the CRC clinical data to determine the effect of the circ_PVT1 and circ_001569 eccentric expressions. Finally, we determined the circ_PVT1 and circ_001569 diagnostic and prognostic values by the receiver operating characteristic (ROC) and the 5-year survival rate analysis. Compared to the healthy controls, circ_PVT1 and circ_001569 expressions were significantly upregulated in the CRC patients' plasma, in a significant fold change of 1.997 and 2.738. Meanwhile, circ_PVT1 and circ_001569 expressions were correlated with tumor node metastasis (TNM) stage, tumor size, and lymph node metastasis. The area under the curves (AUC) of circ_PVT1 and circ_001569 were 0.8389 (95% CI, 0.7889-0.8890) and 0.9016 (95%CI, 0.8588-0.9444). Higher circ_PVT1 and circ_001569 expressions correlated to CRC patients' poor prognosis more than those with lower expressions. In summary, circ_PVT1 and circ_001569 were found to be remarkably up-regulated in CRC patients and may function as a potential diagnostic and prognostic marker for CRC.