Literature DB >> 33653207

Is any but a tiny fraction of handedness variance likely to be due to the external environment?

Chris McManus1.   

Abstract

Non-shared environmental variance (NSEV) accounts for 76% of variance in genetic modelling of handedness. However, it is very misleading to suggest that NSEV, "highlights the importance of non-genetic factors for the ontogenesis of hemispheric asymmetries". NSEV is poorly named, is calculated only by subtraction, and provides no direct evidence for environmental effects in the sense of the external environment. Miller suggested that it would be better named as "residual effect". Mitchell has suggested that much or indeed most of NSEV is "developmental variance" and should be included under the heading of nature rather than nurture, and in handedness, "largely reflect[s] the outcome of randomness in brain development". Overall only a very small proportion of NSEV in handedness is likely to be related to external environmental factors in the usual sense of the term.

Entities:  

Keywords:  Handedness; developmental variance; environmental influences; non-shared environmental variance (NSEV)

Year:  2021        PMID: 33653207     DOI: 10.1080/1357650X.2021.1892126

Source DB:  PubMed          Journal:  Laterality        ISSN: 1357-650X


  3 in total

1.  Light-induced asymmetries in embryonic retinal gene expression are mediated by the vascular system and extracellular matrix.

Authors:  Elisabetta Versace; Paola Sgadò; Julia George; Jasmine L Loveland; Joseph Ward; Peter Thorpe; Lars Juhl Jensen; Karen A Spencer; Silvia Paracchini; Giorgio Vallortigara
Journal:  Sci Rep       Date:  2022-07-15       Impact factor: 4.996

2.  Handedness and its genetic influences are associated with structural asymmetries of the cerebral cortex in 31,864 individuals.

Authors:  Zhiqiang Sha; Antonietta Pepe; Dick Schijven; Amaia Carrión-Castillo; James M Roe; René Westerhausen; Marc Joliot; Simon E Fisher; Fabrice Crivello; Clyde Francks
Journal:  Proc Natl Acad Sci U S A       Date:  2021-11-23       Impact factor: 11.205

3.  DNA methylation in peripheral tissues and left-handedness.

Authors:  Veronika V Odintsova; Matthew Suderman; Fiona A Hagenbeek; Doretta Caramaschi; Jouke-Jan Hottenga; René Pool; Conor V Dolan; Lannie Ligthart; Catharina E M van Beijsterveldt; Gonneke Willemsen; Eco J C de Geus; Jeffrey J Beck; Erik A Ehli; Gabriel Cuellar-Partida; David M Evans; Sarah E Medland; Caroline L Relton; Dorret I Boomsma; Jenny van Dongen
Journal:  Sci Rep       Date:  2022-04-04       Impact factor: 4.379

  3 in total

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