Eduard-Alexandru Bonci1,2, Ștefan Țîțu1,2, Alexandru Marius Petrușan2, Claudiu Hossu2, Vlad Alexandru Gâta1,2, Morvarid Talaeian Ghomi1, Paul Milan Kubelac1,3, Teodora Irina Bonci1, Andra Piciu1,3, Maria Cosnarovici1,3, Liviu Hîțu1, Alexandra Timea Kirsch-Mangu1,4, Diana Cristina Pop1,4, Ioan Cosmin Lisencu1,2, Patriciu Achimaș-Cadariu1,2, Doina Piciu1,5, Hank Schmidt6,7, Bogdan Fetica1,8. 1. 11th Department of Oncological Surgery and Gynecological Oncology, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania. 2. Department of Surgical Oncology, "Prof. Dr. Ion Chiricuță" Institute of Oncology, 400015 Cluj-Napoca, Romania. 3. Department of Medical Oncology, "Prof. Dr. Ion Chiricuță" Institute of Oncology, 400015 Cluj-Napoca, Romania. 4. Department of Radiotherapy, "Prof. Dr. Ion Chiricuță" Institute of Oncology, 400015 Cluj-Napoca, Romania. 5. Department of Nuclear Medicine, "Prof. Dr. Ion Chiricuță" Institute of Oncology, 400015 Cluj-Napoca, Romania. 6. Division of Breast Surgery, Tisch Cancer Institute, Mount Sinai Health System, New York, NY 10029, USA. 7. Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. 8. Department of Anatomical Pathology, "Prof. Dr. Ion Chiricuță" Institute of Oncology, 400015 Cluj-Napoca, Romania.
Abstract
Background and Objectives: Local and distant relapse (LR, DR) in breast cancer vary according to its molecular subtypes, with triple-negative breast cancer (TNBC) being the most aggressive. The surgical resection margin width (SRMW) for breast-conserving surgery (BCS) has been intensely debated, especially for the aforementioned subtype. The aim of this study was to examine the impact of SRMW on LR following BCS in TNBC patients. Materials and Methods: We conducted a retrospective study including all patients with TNBC for whom BCS was performed between 2005 and 2014. Results: Final analysis included a total of 92 patients, with a median tumor size of 2.5 cm (range 0-5 cm) and no distant metastasis at the time of diagnosis. A total of 87 patients had received neoadjuvant and/or adjuvant chemotherapy, and all patients had received adjuvant whole-breast radiotherapy. After a median follow-up of 110.7 months (95% CI, 95.23-126.166), there were 5 local recurrences and 8 regional/distant recurrences with an overall LR rate of 5.4%. The risk of LR and DR was similar between groups of patients with several SRMW cut-off values. Conclusions: Our study supports a safe "no ink on tumor" approach for TNBC patients treated with BCS.
Background and Objectives: Local and distant relapse (LR, DR) in breast cancer vary according to its molecular subtypes, with triple-negative breast cancer (TNBC) being the most aggressive. The surgical resection margin width (SRMW) for breast-conserving surgery (BCS) has been intensely debated, especially for the aforementioned subtype. The aim of this study was to examine the impact of SRMW on LR following BCS in TNBC patients. Materials and Methods: We conducted a retrospective study including all patients with TNBC for whom BCS was performed between 2005 and 2014. Results: Final analysis included a total of 92 patients, with a median tumor size of 2.5 cm (range 0-5 cm) and no distant metastasis at the time of diagnosis. A total of 87 patients had received neoadjuvant and/or adjuvant chemotherapy, and all patients had received adjuvant whole-breast radiotherapy. After a median follow-up of 110.7 months (95% CI, 95.23-126.166), there were 5 local recurrences and 8 regional/distant recurrences with an overall LR rate of 5.4%. The risk of LR and DR was similar between groups of patients with several SRMW cut-off values. Conclusions: Our study supports a safe "no ink on tumor" approach for TNBC patients treated with BCS.
Entities:
Keywords:
breast-conserving surgery; local recurrence; no ink on tumor; surgical margin width; triple-negative breast cancer
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