Yoko Idobe-Fujii1, Ryoko Omoso2, Shinya Fujii3, Hiromitsu Fujiwara2, Yuki Nakamura4, Takahiro Nomi4, Yuichiro Sasaki4, Hiroyuki Sasaki5, Hajime Isomoto6, Yoshikazu Murawaki4. 1. Checkup Center, Saiseikai Sakaiminato General Hospital, 44 Yonegawa-cho, Sakaiminato, Tottori, 684-8555, Japan. yok.fujii@sakaiminato-saiseikai.jp. 2. Clinical Laboratory, Saiseikai Sakaiminato General Hospital, Tottori, Japan. 3. Division of Radiology, Department of Multidisciplinary Internal Medicine, Tottori University Faculty of Medicine, Tottori, Japan. 4. Department of Gastroenterology, Saiseikai Sakaiminato General Hospital, Tottori, Japan. 5. Checkup Center, Saiseikai Sakaiminato General Hospital, 44 Yonegawa-cho, Sakaiminato, Tottori, 684-8555, Japan. 6. Division of Gastroenterology and Nephrology, Department of Multidisciplinary Internal Medicine, Tottori University Faculty of Medicine, Tottori, Japan.
Abstract
PURPOSE: We aimed to clarify the normal values obtained by simultaneous use of shear wave imaging and strain imaging (combinational elastography) in liver and reveal how aging influences them. METHODS: In our checkup center, 257 examinees were diagnosed with normal liver based on questionnaires about liver disease and their drinking history, liver function test results, and ultrasound B-mode study findings. We estimated the values of combinational elastography and considered the correlation between the values and age. A multivariate analysis was performed concerning several features and the liver fibrosis (LF) index. We divided examinees into a younger group (< 65 years old) and an older group (≥ 65 years old), and assessed the effect of age on the LF index. RESULTS: The mean shear wave velocity (Vs) of shear wave measurement (SWM) was 1.10 ± 0.17 m/s (range 0.84-1.93), and the mean LF index of real-time tissue elastography (RTE) was 1.371 ± 0.458 (range 0.258-3.173). There was no significant correlation between Vs and age. However, the LF index increased significantly with age. The multivariate analysis showed that age (P < 0.001) and BMI (P < 0.05) significantly affected the LF index. Indeed, the LF index in the older group was significantly higher than that in the younger group (P < 0.001). CONCLUSION: In adult liver, the normal Vs of SWM was 1.10 ± 0.17 m/s, and the normal LF index of RTE was 1.371 ± 0.458. The LF index increased significantly with age in contrast to Vs; therefore, the influence of age should be considered when using combinational elastography.
PURPOSE: We aimed to clarify the normal values obtained by simultaneous use of shear wave imaging and strain imaging (combinational elastography) in liver and reveal how aging influences them. METHODS: In our checkup center, 257 examinees were diagnosed with normal liver based on questionnaires about liver disease and their drinking history, liver function test results, and ultrasound B-mode study findings. We estimated the values of combinational elastography and considered the correlation between the values and age. A multivariate analysis was performed concerning several features and the liver fibrosis (LF) index. We divided examinees into a younger group (< 65 years old) and an older group (≥ 65 years old), and assessed the effect of age on the LF index. RESULTS: The mean shear wave velocity (Vs) of shear wave measurement (SWM) was 1.10 ± 0.17 m/s (range 0.84-1.93), and the mean LF index of real-time tissue elastography (RTE) was 1.371 ± 0.458 (range 0.258-3.173). There was no significant correlation between Vs and age. However, the LF index increased significantly with age. The multivariate analysis showed that age (P < 0.001) and BMI (P < 0.05) significantly affected the LF index. Indeed, the LF index in the older group was significantly higher than that in the younger group (P < 0.001). CONCLUSION: In adult liver, the normal Vs of SWM was 1.10 ± 0.17 m/s, and the normal LF index of RTE was 1.371 ± 0.458. The LF index increased significantly with age in contrast to Vs; therefore, the influence of age should be considered when using combinational elastography.
Authors: Christoph F Dietrich; Jeffrey Bamber; Annalisa Berzigotti; Simona Bota; Vito Cantisani; Laurent Castera; David Cosgrove; Giovanna Ferraioli; Mireen Friedrich-Rust; Odd Helge Gilja; Ruediger Stephan Goertz; Thomas Karlas; Robert de Knegt; Victor de Ledinghen; Fabio Piscaglia; Bogdan Procopet; Adrian Saftoiu; Paul S Sidhu; Ioan Sporea; Maja Thiele Journal: Ultraschall Med Date: 2017-04-13 Impact factor: 6.548