Literature DB >> 336505

Calcium antagonists and islet function. XI. Effect of nifedipine.

W J Malaisse, A C Boschero.   

Abstract

Nifedipine inhibits calcium-45 net uptake and glucose-induced insulin release in rat pancreatic islets, without affecting glucose oxidation and calcium-45 efflux. These findings are compatible with the view that nifedipine inhibits the entry of calcium in the B cell, by interfering with the plasma membrane ionophoretic channels.

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Year:  1977        PMID: 336505     DOI: 10.1159/000178801

Source DB:  PubMed          Journal:  Horm Res        ISSN: 0301-0163


  18 in total

Review 1.  Nifedipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in ischaemic heart disease, hypertension and related cardiovascular disorders.

Authors:  E M Sorkin; S P Clissold; R N Brogden
Journal:  Drugs       Date:  1985-09       Impact factor: 9.546

2.  Different insulin-secretory responses to calcium-channel blockers in islets of lean and obese (ob/ob) mice.

Authors:  M A Black; L A Fournier; H M Heick; N Bégin-Heick
Journal:  Biochem J       Date:  1988-01-15       Impact factor: 3.857

3.  Effects of calcium and Bay K-8644 on calcium currents in adrenal medullary chromaffin cells.

Authors:  V Ceña; A Stutzin; E Rojas
Journal:  J Membr Biol       Date:  1989-12       Impact factor: 1.843

4.  Role of calcium in the modulation of ornithine decarboxylase activity in isolated pig granulosa cells in vitro.

Authors:  J D Veldhuis; J M Hammond
Journal:  Biochem J       Date:  1981-06-15       Impact factor: 3.857

Review 5.  Adverse reactions to calcium antagonists.

Authors:  J G Lewis
Journal:  Drugs       Date:  1983-02       Impact factor: 9.546

6.  Insulinotropic effects of hypoglycaemic and hyperglycaemic sulphonamides: the ionophoretic hypothesis.

Authors:  E Couturier; W J Malaisse
Journal:  Diabetologia       Date:  1980-10       Impact factor: 10.122

7.  Hyperglycaemic effect of nifedipine.

Authors:  R H Greenwood
Journal:  Br Med J (Clin Res Ed)       Date:  1982-01-02

8.  Effect of nifedipine on glucose potentiation of the acute insulin response to arginine in non-insulin-dependent diabetics.

Authors:  M Krempf; S Ranganatan; P Ritz; J M Garnier; B Charbonnel
Journal:  Eur J Clin Pharmacol       Date:  1991       Impact factor: 2.953

9.  Effects of the calcium channel agonist, BAY K 8644, on electrical activity in mouse pancreatic B-cells.

Authors:  P Lebrun; I Atwater
Journal:  Biophys J       Date:  1985-12       Impact factor: 4.033

10.  Calcium antagonists and histamine secretion from rat peritoneal mast cells.

Authors:  M Ennis; P W Ind; F L Pearce; C T Dollery
Journal:  Agents Actions       Date:  1983-04
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