| Literature DB >> 33650490 |
William L Hamilton1,2, Gerry Tonkin-Hill3, Emily R Smith4, Dinesh Aggarwal2,5, Charlotte J Houldcroft6, Ben Warne1,2, Luke W Meredith6, Myra Hosmillo6, Aminu S Jahun6, Martin D Curran7, Surendra Parmar7, Laura G Caller6,8, Sarah L Caddy6, Fahad A Khokhar2, Anna Yakovleva6, Grant Hall6, Theresa Feltwell6, Malte L Pinckert6, Iliana Georgana6, Yasmin Chaudhry6, Colin S Brown5, Sonia Gonçalves3, Roberto Amato3, Ewan M Harrison3, Nicholas M Brown1,7, Mathew A Beale3, Michael Spencer Chapman3,9, David K Jackson3, Ian Johnston3, Alex Alderton3, John Sillitoe3, Cordelia Langford3, Gordon Dougan2, Sharon J Peacock2, Dominic P Kwiatowski3, Ian G Goodfellow6, M Estee Torok1,2.
Abstract
COVID-19 poses a major challenge to care homes, as SARS-CoV-2 is readily transmitted and causes disproportionately severe disease in older people. Here, 1167 residents from 337 care homes were identified from a dataset of 6600 COVID-19 cases from the East of England. Older age and being a care home resident were associated with increased mortality. SARS-CoV-2 genomes were available for 700 residents from 292 care homes. By integrating genomic and temporal data, 409 viral clusters within the 292 homes were identified, indicating two different patterns - outbreaks among care home residents and independent introductions with limited onward transmission. Approximately 70% of residents in the genomic analysis were admitted to hospital during the study, providing extensive opportunities for transmission between care homes and hospitals. Limiting viral transmission within care homes should be a key target for infection control to reduce COVID-19 mortality in this population.Entities:
Keywords: COVID-19; SARS-CoV-2; epidemiology; genetics; genomics; global health; virus
Mesh：
Year: 2021 PMID： 33650490 PMCID： PMC7997667 DOI： 10.7554/eLife.64618
Source DB: PubMed Journal: Elife ISSN： 2050-084X Impact factor: 8.140