| Literature DB >> 33649986 |
Naja Dam Mygind1,2, Signe Holm Nielsen3,4, Marie Mide Michelsen5, Adam Pena6, Daria Frestad Bechsgaard7, Elena Suhrs5, Kira Bang Bove5, Federica Genovese3, Henning Bay Nielsen8, Morten Karsdal3, Niels Vejlstrup9, Eva Prescott5, Jens Kastrup9.
Abstract
Angina and no obstructive coronary artery disease (CAD) have an unfavorable prognosis, possibly due to diffuse myocardial fibrosis (DMF). In DMF the proteoglycans biglycan and versican are actively remodeled by matrix metalloproteinase. We investigated biglycan and versican in females with angina and possible DMF assessed by cardiac magnetic resonance (CMR). Seventy-one females with angina and no obstructive CAD were included. Asymptomatic females served as controls. Versican and biglycan were measured and CMR was performed measuring extracellular volume. Biglycan and versican levels were higher in symptomatic females compared with controls; 31.4 ng/mL vs. 16.4 ng/mL (p < 0.001) and 2.1 ng/mL vs. 1.8 ng/mL (p < 0.001) and moderately correlated to extracellular volume (r2 = 0.38, p<0.001 and r2 = 0.26, p = 0.015). Turnover of biglycan and versican was increased in angina females compared with controls and associated with extracellular volume, supporting a link between angina with no obstructive CAD and fibrotic remodeling.Entities:
Keywords: Angina pectoris; Cardiac magnetic resonance; Coronary microvascular disease; Diffuse myocardial fibrosis; Extracellular matrix; Proteoglycan; T1 mapping
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Year: 2021 PMID： 33649986 DOI： 10.1007/s12265-021-10106-y
Source DB: PubMed Journal: J Cardiovasc Transl Res ISSN： 1937-5387 Impact factor: 4.132