Hassan Boskabadi1, Maryam Marefat1, Gholamali Maamouri1, Majid Abrishami2, Mojtaba Abrishami2, Nasser Shoeibi2, Mostafa Soltan Sanjari3, Majid Ghayour Mobarhan4, Seyed Reza Habibzadeh Shojaei5, Shima Tavallaei6, Fathemeh Sanei7, Mahsa Kakavandi7, Ali Moradi8,9, Maryam Zakerihamidi10. 1. Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 2. Eye Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR, Iran. 3. Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. 4. Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 5. Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 6. Department of Biochemistry, Faculty of Medicine, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 7. School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR, Iran. 8. Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 9. Clinical Research Development Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. 10. Department of Midwifery, School of Medical Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran. maryamzakerihamidi@yahoo.co.nz.
Abstract
INTRODUCTION: Retinopathy of prematurity (RoP) is a vasoproliferative disorder caused by the abnormal development of retinal vessels in premature neonates. It is one of the major causes of childhood blindness, which is increasing with the increasing survival rate of low birth weight and premature neonates. This study has aimed to evaluate the role of oxidative stress and peroxidant antioxidant balance (PAB) in the pathogenesis and prediction of RoP. MATERIALS AND METHODS: A total of 154 neonates weighing <1500 g admitted at the NICU of Ghaem Hospital, Mashhad, Iran, were enrolled in this cross-sectional study between 2018 and 2020. Blood samples were collected on the first day of birth to assess the peroxidant and antioxidant balance. The demographic, prenatal, and clinical course and postnatal problems were also recorded. The neonates were examined for RoP and divided into control (healthy) and affected (ROP) groups. RESULTS: There were significant differences between the two groups in gestational age, duration of oxygen therapy, and first and fifth minute Apgar score (P < 0.005). The mean PAB in infants without and with ROP was 19.79 HK (Hamidi-Koliakos) and 38.45 HK, respectively (P < 0.0001). Also, the mean PAB in neonates with ROP grade 1 and 2 was 36.69 HK and 45.53 HK, respectively (P = 0.002). CONCLUSION: According to our findings, the PAB level can be helpful in predicting ROP incidence. With increasing PAB, the possibility of ROP severity will increase.
INTRODUCTION: Retinopathy of prematurity (RoP) is a vasoproliferative disorder caused by the abnormal development of retinal vessels in premature neonates. It is one of the major causes of childhood blindness, which is increasing with the increasing survival rate of low birth weight and premature neonates. This study has aimed to evaluate the role of oxidative stress and peroxidant antioxidant balance (PAB) in the pathogenesis and prediction of RoP. MATERIALS AND METHODS: A total of 154 neonates weighing <1500 g admitted at the NICU of Ghaem Hospital, Mashhad, Iran, were enrolled in this cross-sectional study between 2018 and 2020. Blood samples were collected on the first day of birth to assess the peroxidant and antioxidant balance. The demographic, prenatal, and clinical course and postnatal problems were also recorded. The neonates were examined for RoP and divided into control (healthy) and affected (ROP) groups. RESULTS: There were significant differences between the two groups in gestational age, duration of oxygen therapy, and first and fifth minute Apgar score (P < 0.005). The mean PAB in infants without and with ROP was 19.79 HK (Hamidi-Koliakos) and 38.45 HK, respectively (P < 0.0001). Also, the mean PAB in neonates with ROP grade 1 and 2 was 36.69 HK and 45.53 HK, respectively (P = 0.002). CONCLUSION: According to our findings, the PAB level can be helpful in predicting ROP incidence. With increasing PAB, the possibility of ROP severity will increase.
Authors: Hassan Boskabadi; Maryam Zakerihamidi; Mohammad Heidarzadeh; Amir Avan; Majid Ghayour-Mobarhan; Gordon A Ferns Journal: J Matern Fetal Neonatal Med Date: 2016-09-21
Authors: Mehdi Bakhshaee; Hassan Boskabadi; Malihe Hassanzadeh; Navid Nourizadeh; Mohammad Mehdi Ghassemi; Kamran Khazaeni; Toktam Moghiman; Mohammad Reza Tale Journal: Otolaryngol Head Neck Surg Date: 2008-12 Impact factor: 3.497