| Literature DB >> 3364957 |
C L Mintzer1, P Deloron, A Rice-Ficht, D Durica, D K Struck, C A Roessner, C Nicolau, G M Ihler.
Abstract
Chemicals entrapped in erythrocytes by hypotonic hemolysis can be assessed for possible antiparasitic activity both in vivo and in vitro, regardless of whether they are able to diffuse into erythrocytes readily. Inositol hexaphosphate, a highly charged compound, produced a dramatic lowering of the percentage of cells infected by Babesia microti in vivo and both B. microti and Plasmodium falciparum in vitro. Several possible mechanisms for this observation are discussed.Entities:
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Year: 1988 PMID： 3364957 PMCID： PMC172182 DOI： 10.1128/AAC.32.3.391
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191