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Literature DB >> 3364947

Effect of oral activated charcoal on tobramycin clearance.

R L Davis¹, J R Koup, R A Roon, K E Opheim, A N Smith.

Abstract

To evaluate the effect of activated charcoal on aminoglycoside pharmacokinetics, six healthy volunteers received tobramycin intravenously with and without multiple oral doses of activated charcoal. Activated charcoal did not have a statistically significant effect on any pharmacokinetic parameter. We conclude that activated charcoal does not enhance tobramycin clearance in subjects with normal renal function when concentrations in serum are within the therapeutic range.

Entities: Chemical

Mesh：

Substances：
Charcoal
Tobramycin

Year: 1988 PMID： 3364947 PMCID： PMC172152 DOI： 10.1128/AAC.32.2.274

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

1. Pharmacokinetics of tobramycin in patients with stable renal impairment, patients undergoing peritoneal dialysis, and patients on chronic hemodialysis.

Authors: G Jaffe; B R Meyers; S Z Hirschman
Journal: Antimicrob Agents Chemother Date: 1974-06 Impact factor: 5.191

2. Effect of peritoneal dialysis on serum levels of tobramycin and clindamycin.

Authors: R F Malacoff; F O Finkelstein; V T Andriole
Journal: Antimicrob Agents Chemother Date: 1975-11 Impact factor: 5.191

3. Gastrointestinal clearance of drugs with activated charcoal.

Authors: G Levy
Journal: N Engl J Med Date: 1982-09-09 Impact factor: 91.245

4. Effect of activated charcoal on absorption and elimination of phenobarbitone, carbamazepine and phenylbutazone in man.

Authors: P J Neuvonen; E Elonen
Journal: Eur J Clin Pharmacol Date: 1980-01 Impact factor: 2.953

Review 10. The aminoglycosides.

Authors: A M Ristuccia; B A Cunha
Journal: Med Clin North Am Date: 1982-01 Impact factor: 5.456

1 in total

1. Influence of activated charcoal on the pharmacokinetics of moxifloxacin following intravenous and oral administration of a 400 mg single dose to healthy males.

Authors: H Stass; D Kubitza; J-G Möller; H Delesen
Journal: Br J Clin Pharmacol Date: 2005-05 Impact factor: 4.335

1 in total

Effect of oral activated charcoal on tobramycin clearance.

1. Pharmacokinetics of tobramycin in patients with stable renal impairment, patients undergoing peritoneal dialysis, and patients on chronic hemodialysis.

2. Effect of peritoneal dialysis on serum levels of tobramycin and clindamycin.

3. Gastrointestinal clearance of drugs with activated charcoal.

4. Effect of activated charcoal on absorption and elimination of phenobarbitone, carbamazepine and phenylbutazone in man.

5. Effect of oral charcoal and urine pH on dextropropoxyphene pharmacokinetics.

6. Effect of activated charcoal on the pharmacokinetics of high-dose methotrexate.

7. Model for theophylline overdose treatment with oral activated charcoal.

8. Tobramycin kinetics during continuous ambulatory peritoneal dialysis.

9. Acceleration of the body clearance of phenobarbital by oral activated charcoal.

Review 10. The aminoglycosides.

1. Influence of activated charcoal on the pharmacokinetics of moxifloxacin following intravenous and oral administration of a 400 mg single dose to healthy males.