| Literature DB >> 33649297 |
André C Ferreira1,2,3, Vinicius Cardoso Soares4,5, Isaclaudia G de Azevedo-Quintanilha4, Suelen da Silva Gomes Dias4, Natalia Fintelman-Rodrigues4,6, Carolina Q Sacramento4,6, Mayara Mattos4,6, Caroline S de Freitas4,6, Jairo R Temerozo7,8, Lívia Teixeira4, Eugenio Damaceno Hottz4,9, Ester A Barreto4, Camila R R Pão4, Lohanna Palhinha4, Milene Miranda10, Dumith Chequer Bou-Habib7,8, Fernando A Bozza11,12, Patrícia T Bozza4, Thiago Moreno L Souza13,14.
Abstract
Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with leukopenia and uncontrolled inflammatory response in critically ill patients. A better comprehension of SARS-CoV-2-induced monocyte death is essential for the identification of therapies capable to control the hyper-inflammation and reduce viral replication in patients with 2019 coronavirus disease (COVID-19). Here, we show that SARS-CoV-2 engages inflammasome and triggers pyroptosis in human monocytes, experimentally infected, and from patients under intensive care. Pyroptosis associated with caspase-1 activation, IL-1ß production, gasdermin D cleavage, and enhanced pro-inflammatory cytokine levels in human primary monocytes. At least in part, our results originally describe mechanisms by which monocytes, a central cellular component recruited from peripheral blood to respiratory tract, succumb to control severe COVID-19.Entities:
Year: 2021 PMID： 33649297 PMCID： PMC7919254 DOI： 10.1038/s41420-021-00428-w
Source DB: PubMed Journal: Cell Death Discov ISSN： 2058-7716