Literature DB >> 33649289

Metformin targets Clusterin to control lipogenesis and inhibit the growth of bladder cancer cells through SREBP-1c/FASN axis.

Jun Deng1, Mei Peng2,3, Sichun Zhou1, Di Xiao1, Xin Hu1, Simeng Xu1, Jingtao Wu1, Xiaoping Yang4.   

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Year:  2021        PMID： 33649289      PMCID： PMC7921554          DOI： 10.1038/s41392-021-00493-8

Source DB:  PubMed          Journal:  Signal Transduct Target Ther        ISSN： 2059-3635


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  5 in total

1.  Melittin inhibits tumor growth and decreases resistance to gemcitabine by downregulating cholesterol pathway gene CLU in pancreatic ductal adenocarcinoma.

Authors:  Xinjing Wang; Jing Xie; Xiongxiong Lu; Hongzhe Li; Chenlei Wen; Zhen Huo; Junjie Xie; Minmin Shi; Xiaomei Tang; Hao Chen; Chenghong Peng; Yuan Fang; Xiaxing Deng; Baiyong Shen
Journal:  Cancer Lett       Date:  2017-04-17       Impact factor: 8.679

2.  PRE-surgical Metformin In Uterine Malignancy (PREMIUM): a Multi-Center, Randomized Double-Blind, Placebo-Controlled Phase III Trial.

Authors:  Sarah J Kitson; Zoe Maskell; Vanitha N Sivalingam; Jennifer L Allen; Saad Ali; Sean Burns; Kyle Gilmour; Rahamatulla Latheef; Richard J Slade; Philip W Pemberton; Joseph Shaw; W David Ryder; Henry C Kitchener; Emma J Crosbie
Journal:  Clin Cancer Res       Date:  2018-12-18       Impact factor: 12.531

3.  High efficacy of intravesical treatment of metformin on bladder cancer in preclinical model.

Authors:  Mei Peng; Qiongli Su; Qing Zeng; Le Li; Zhihong Liu; Lei Xue; Yan Cheng; Yanjun Huang; Ting Tao; Hongwei Lv; Xiaohui Li; Xiaojun Tao; Peng Guo; Alex F Chen; Xiaoping Yang
Journal:  Oncotarget       Date:  2016-02-23

Review 4.  Heat Shock Proteins and Ovarian Cancer: Important Roles and Therapeutic Opportunities.

Authors:  Abdullah Hoter; Hassan Y Naim
Journal:  Cancers (Basel)       Date:  2019-09-18       Impact factor: 6.639

5.  Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation.

Authors:  Dongxin Lin; Chen Wu; Yupei Zhao; Chengcheng Wang; Taiping Zhang; Quan Liao; Menghua Dai; Junchao Guo; Xinyu Yang; Wen Tan
Journal:  Protein Cell       Date:  2020-07-31       Impact factor: 14.870
  5 in total
  8 in total

Review 1.  The role and function of CLU in cancer biology and therapy.

Authors:  Yefei Zhang; Xiang Lv; Liming Chen; Yan Liu
Journal:  Clin Exp Med       Date:  2022-09-13       Impact factor: 5.057

2.  Inhibitory role of proguanil on the growth of bladder cancer via enhancing EGFR degradation and inhibiting its downstream signaling pathway to induce autophagy.

Authors:  Di Xiao; Xin Hu; Mei Peng; Jun Deng; Sichun Zhou; Simeng Xu; Jingtao Wu; Xiaoping Yang
Journal:  Cell Death Dis       Date:  2022-05-25       Impact factor: 9.685

3.  Identification and validation of a novel signature for prediction the prognosis and immunotherapy benefit in bladder cancer.

Authors:  Yichi Zhang; Yifeng Lin; Daojun Lv; Xiangkun Wu; Wenjie Li; Xueqing Wang; Dongmei Jiang
Journal:  PeerJ       Date:  2022-01-25       Impact factor: 2.984

Review 4.  Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms.

Authors:  Sheng Chen; Donghao Gan; Sixiong Lin; Yiming Zhong; Mingjue Chen; Xuenong Zou; Zengwu Shao; Guozhi Xiao
Journal:  Theranostics       Date:  2022-03-06       Impact factor: 11.600

5.  Metformin Use on Incidence and Oncologic Outcomes of Bladder Cancer Patients With T2DM: An Updated Meta-Analysis.

Authors:  Chen-Qian Liu; Jian-Xuan Sun; Jin-Zhou Xu; Xiao-Yuan Qian; Sen-Yuan Hong; Meng-Yao Xu; Ye An; Qi-Dong Xia; Jia Hu; Shao-Gang Wang
Journal:  Front Pharmacol       Date:  2022-04-07       Impact factor: 5.988

Review 6.  Protective effects of metformin in various cardiovascular diseases: Clinical evidence and AMPK-dependent mechanisms.

Authors:  Yizhi Bu; Mei Peng; Xinyi Tang; Xu Xu; Yifeng Wu; Alex F Chen; Xiaoping Yang
Journal:  J Cell Mol Med       Date:  2022-09-02       Impact factor: 5.295

7.  Analysis and identification of the necroptosis landscape on therapy and prognosis in bladder cancer.

Authors:  Zihan Zhao; Ning Jiang; Yulin Zhang; Yuhao Bai; Tianyao Liu; Tianhang Li; Hongqian Guo; Rong Yang
Journal:  Front Genet       Date:  2022-09-29       Impact factor: 4.772

8.  Landscape of the oncogenic role of fatty acid synthase in human tumors.

Authors:  Xulei Huo; Lairong Song; Da Li; Ke Wang; Yali Wang; Feng Chen; Liwei Zhang; Liang Wang; Junting Zhang; Zhen Wu
Journal:  Aging (Albany NY)       Date:  2021-12-08       Impact factor: 5.682
  8 in total

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